agouti-related peptide


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agouti-related peptide (AgRP),

a peptide released with neuropeptide Y from specific neurons of the arcuate nucleus. These neurons are stimulated by ghrelin and inhibited by neuropeptide PYY and leptin. Release of agouti-related peptide and neuropeptide Y stimulates appetite while reducing metabolism.
See also: ghrelin, leptin, neuropeptide Y.
Farlex Partner Medical Dictionary © Farlex 2012

Agouti-Related Peptide

A peptide produced in the arcuate nucleus in the hypothalamus, which increases appetite (an action countered by leptin), but reduces the rate of metabolism and energy expenditure. It is increased in obese subjects.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
The two cell groups are called pro-opiomelanocortin (POMC) and agouti-related peptide (AgRP) cells.
Meanwhile, AgRP or Agouti-related peptide neurons stimulate feeding and suppress energy usage.
[2] Nonstandard abbreviations: DREADD, designer receptors exclusively activated by designer drugs; ARC, arcuate nucleus; PVN, paraventricular nucleus; VMH, ventromedial hypothalamus; LH, lateral hypothalamus; POMC, proopiomelanocortin; CART, cocaine- and amphetamine-related transcript; NPY, neuropeptide Y; AgRP, agouti-related peptide; SIM 1, single-minded homolog 1; [alpha]-MSH, alpha-melanocyte-stimulating hormone; MCH, melanin-concentrating hormone; BDNF, brain-derived neurotrophic factor; NTS, nucleus of the solitary tract; PBN, parabrachial nucleus.
Abusnana et al., "Hypothalamic localization of the feeding effect of agouti-related peptide and amelanocyte-stimulating hormone," Diabetes, vol.
Davidowa, "Increased inhibition by agouti-related peptide of ventromedial hypothalamic neurons in rats overweight due to early postnatal overfeeding," Neuroscience Letters, vol.
The modest reduction of long-chain acyl-CoAs within the arcuate nucleus (ARC) would increase the expression of both agouti-related peptide (AgRP) and neuropeptide Y (NPY) and enhance feed intake (Obici et al., 2003).
corticotropin-releasing hormone (CRH), neuropeptide Y (NPY), agouti-related peptide (AgRP), pro-opiomelanocortin (POMC)) and fatty acid synthase (FAS).
Coordinate regulation of neuropeptide Y and agouti-related peptide gene expression by estrogen depends on the ratio of estrogen receptor (ER) a to ERa in clonal hypothalamic neurons.
Agouti-Related Peptide and Proopiomelanocortin Peptides.
Washington, Feb 9 ( ANI ): There are two vital cell types in the brain that are essential for the regulation of feeding behaviours - agouti-related peptide (AgRP)-expressing neurons and proopiomelancortin (POMC)-expressing neurons.
The importance of ghrelin as a "hunger hormone" with orexigenic effects mediated by the hypothalamic peptides, agouti-related peptide, and neuropeptide Y, and the fact that it is the most potent peripheral signal of diminishing energy stores, implies that ghrelin release might be the most important of the many redundant mechanisms ensuring human survival in times of famine (4).
Within the ARC, scientists have also identified two types of leptin-responsive neurons: the Agouti-related peptide (AgRP) neurons, which stimulate appetite and the pro-opiomelanocortin (POMC) neurons, which curb appetite.