agonistic antibody


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agonistic antibody

An antibody that stimulates or activates an organ. E.g., agonistic antibodies against the thyrotropin receptor in Grave disease stimulate the thyroid gland to release thyroid hormones that produce hyperthyroidism.
See also: antibody
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Because it has been shown that agonistic anti-4-1BB antibody treatment does not induce inflammatory responses in endothelial cells when 4-1BB expression is low [14], we thought that 4-1BB expression on muscle cells might not be strong enough in the noninflamed condition to lead to stimulation by the agonistic antibody. In agreement with this view, pretreatment with TNF[alpha] markedly upregulated 4-1BB expression, and subsequent treatment with agonistic antibody enhanced inflammatory cytokine production (TNF[alpha], IL-6, and MCP-1) in muscle cells from WT mice; moreover, these changes were completely abrogated in 4-1BB-deficient muscle cells, confirming the need for 4-1BB stimulation.
The company's lead product candidate, CTX-471, is a fully human agonistic antibody of CD137, which is in a Phase 1 study in patients with inadequate responses to PD-1/PD-L1 checkpoint inhibitors.
Dr Karin Enell Smith, senior scientist Immuno-oncology at Alligator Bioscience, will hold an oral presentation with the title, 'ATOR-1017 - A Tumour Directed Fc?-Receptor Cross Linking Dependent 4-1BB Agonistic Antibody' on 18 March 2019 at 17:45 hours GMT.
Alligator Bioscience AB (STO:ATORX), a clinical-stage biotechnology company developing tumour-directed immuno-oncology antibody drug, announced on Tuesday the publication of the results from a clinical phase I first-in-human study of the CD40 agonistic antibody ADC-1013 (JNJ-64457107).