FBXW7

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FBXW7

A gene on chromosome 4q31.3 that encodes a so-called F-box protein, which contains a 40 amino acid protein-interacting motif (the F box). F-box proteins form a complex with SKP1 and cullin, resulting in phosphorylation-dependent ubiquitination and ubiquitin-mediated degradation of targeted proteins. F-box proteins are divided into three classes based on the presence of:
(1) WD-40 repeats—as is the case with this F-box protein (Fbws class),
(2) leucine-rich repeats (Fbls class); or
(3) the presence or absence of other protein-protein interacting domains (Fbxs class).
The FBXW7 protein product binds directly to cyclin E, targeting it for ubiquitin-mediated degradation.

Molecular pathology
FBXW7 mutations are found in ovarian and breast cancer cell lines, implicating FBXW7’s potential role in carcinogenesis.
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The second time was the day before yesterday, at daybreak, on the journey at the station of Malaya Vishera, and the third time was two hours ago in the room where I am staying.
"Y-yes, I have seen them, but only once in my life, six years ago. I had a serf, Filka; just after his burial I called out forgetting
I thought of that long ago. If you believe in a future life, you could believe in that, too."
"I am old and rheumatic, and my dancing days were over long ago. But either of these gay young gentlemen will be glad of so pretty a partner."
"She promised me her hand, fifty years ago!" exclaimed Mr.
A signature made by a hand which vanished out of this life near a thousand years ago, is a more impressive thing than even a ruined castle.
The walls of the chancel are of porcelain, all pictured over with figures of almost life size, very elegantly wrought and dressed in the fanciful costumes of two centuries ago. The design was a history of something or somebody, but none of us were learned enough to read the story.
I raised her hand and touched it with my lips, as we whimsical old fellows do when some gracious girl makes us to hear the key in the lock of long ago. "Why, ma'am," I said, "it is a pretty notion, and there may be something in it.
I have already told you, reader, that this conversation took place no longer ago than yesterday.
"You spoke, a little time ago," she continued, "of some great crisis with which your country might soon come face to face.
"Let me remind you, then, of what we were saying a little time ago," he went on.
Do not you ever read the history of your country as it was many hundreds of years ago, before this ugly thing they call civilization weakened the sinews of our race and besmirched the very face of duty?