FBXW7

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FBXW7

A gene on chromosome 4q31.3 that encodes a so-called F-box protein, which contains a 40 amino acid protein-interacting motif (the F box). F-box proteins form a complex with SKP1 and cullin, resulting in phosphorylation-dependent ubiquitination and ubiquitin-mediated degradation of targeted proteins. F-box proteins are divided into three classes based on the presence of:
(1) WD-40 repeats—as is the case with this F-box protein (Fbws class),
(2) leucine-rich repeats (Fbls class); or
(3) the presence or absence of other protein-protein interacting domains (Fbxs class).
The FBXW7 protein product binds directly to cyclin E, targeting it for ubiquitin-mediated degradation.

Molecular pathology
FBXW7 mutations are found in ovarian and breast cancer cell lines, implicating FBXW7’s potential role in carcinogenesis.
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Blanche has been in Roulettenberg before, for she was staying here three seasons ago.
And this was the reason that, long ago, In this kingdom by the sea, A wind blew out of a cloud by night Chilling my ANNABEL LEE; So that her high-born kinsmen came And bore her away from me, To shut her up, in a sepulchre In this kingdom by the sea.
He had many years ago received such a description of Miss Anne Elliot as had inspired him with the highest idea of her merit, and excited the warmest curiosity to know her.
It was polished and hard, and in as excellent a state of preservation as if the dread tragedy on Calvary had occurred yesterday instead of eighteen centuries ago.
Washington's character from a very simple incident many years ago.
But even if we assume that fifty years ago Alexander I was mistaken in his view of what was good for the people, we must inevitably assume that the historian who judges Alexander will also after the lapse of some time turn out to be mistaken in his view of what is good for humanity.
I should have had to be carrying David long ago and resting on every seat like old Mr.
The Admiral wrote me, a few weeks ago, that he saw no hope for anything else.
My dream personality lived in the long ago, before ever man, as we know him, came to be; and my other and wake-a-day personality projected itself, to the extent of the knowledge of man's existence, into the substance of my dreams.
Now the people who lived in the British Isles long ago were not English.
One day, over a hundred years ago, Ursula Townley was waiting for Kenneth MacNair in a great beechwood, where brown nuts were falling and an October wind was making the leaves dance on the ground like pixy-people.
In a way she just seems to me the little girl Matthew brought home here fourteen years ago.