Gene mutation is considered to be responsible for agnogenic
EOEEs. With the extensive application of next-generation sequencing (NGS) and whole exome sequencing, EOEE-related gene panels make for early and efficient diagnosis of EOEE patients and also help detecting more EOEE susceptibility genes. STXBP1, ARX, SLC25A22, and KCNQ2 are some of the susceptibility genes for OS, while CDKL5, ALG13, and SCN1A are considered to be responsible for WS.
Cytogenetics of agnogenic
myeloid metaplasia: a study of 61 patients.
Excluded from this discussion are polycythemia vera, essential thrombocythemia, and agnogenic
myeloid metaplasia, which are also considered myeloproliferative disorders along with CLMO, but are generally not leukemic.
The cases were divided into posttraumatic group ( n = 257), postoperative group ( n = 8), endogenous group ( n = 2), infectious corneal ulcer group ( n = 1), and agnogenic
group ( n = 3) with regard to etiology.
Immune disorders in agnogenic
myeloid metaplasia: relations to myelofibrosis.
Perirenal extramedullary hematopoiesis in agnogenic
myeloid metaplasia: MR imaging findings.
It is crucial to role out CML by performing the bcr gene rearrangement test, since the therapeutic approach in CML is very different compared to therapy in essential thrombocythemia, polycythemia vera, or agnogenic
myeloid metaplasia with myelofibrosis.
It can be distinguished from agnogenic
myeloid metaplasia by the absence of splenomegaly, teardrop RBCs and leukoerythroblastosis in peripheral blood smears, and from acute megakaryoblastic leukemia by the absence or small percentages of blasts of megakaryocytic origin .