The chromatographic properties of compound V showed that it was an
aglycone.
Whether flavonoids are present in
aglycone or glycoside form can have profound impact on their pharmacokinetic and pharmacodynamic characteristics (Murato and Terao, 2003; Walle, 2004), with obvious potential implications for the safety and efficacy of the product.
The rate of increase of CNP corresponded to the decrease of GalG2CNP; the other
aglycone fragments (G2CNP and G1CNP) did not appear.
Characterisation of phenolic and secoiridoid
aglycones present in virgin olive oil by gas chromatography-chemical ionisation mass spectrometry.
Dramatic chemical changes were found that the contents of 4 flavonoid
aglycones remarkably increased while those of 7 glycosides significantly reduced which suggested that sulfurumigation induced flavonoid glycosides transformed into aglycons by hydrolysis reaction.
Genistein
aglycone reverses glucocorticoid-induced osteoporosis and increases bone breaking strength in rats: a comparative study with alendronate.
However, it is interesting to note that diosmin is hydrolyzed by enzymes of the intestinal microflora before absorption of its
aglycone diosmetin in vivo (Campanero et al.
Osteogen ic effects of flavonoid
aglycones from an osteoprotective fraction of Deynaria fortunei--an in vitro efficacy study.
glucuronic acid and sulphate) to give the
aglycone fragment ion (Prasain and Barnes 2007).
15956 [M+H] Lignan
aglycone of methylation) * 4 Artigenin (Mataresinol of 373.
Sutovsky also draws attention to the fact that Solbar's products contain high levels of genistin and genistein in a glycoside conjugate to
aglycone ratio that matches the profile of isoflavones as they naturally occur in the soybean.
A multicenter, randomized, double-blind, placebo-controlled, 24-month trial was conducted to assess the effects of daily supplementation with 80 or 120 mg of soy hypocotyl
aglycone isoflavones, plus calcium and vitamin D, on bone changes in 403 postmenopausal women.
