In the biosynthesis of these compounds, the glycosidic bonds cannot be formed by the direct dehydration reactions of saccharide units and its
aglycon parts.
There is some evidence that flavonoids in their glycon form seem to be more inhibitory effect on rotavirus infectivity than flavonoids in their
aglycon form (120).
The strength of its formulas along with its standardization is vitally important because the effectiveness of
aglycon sapogenins is dose-dependent.
When the researchers damaged the
aglycon portion of the vancomycin derivative, rendering it unable to bind, the altered molecule still killed bacteria effectively.
With the successful synthesis of 4a-c in mind, we decided investigate others
aglycons in the hex-2-enopyranoside structure.
This speculation has been supported by several lines of evidence, such as 1) unmodified glycans are poorly glucosylated by UGGT, 2) M9 containing n-propyl, a modestly hydrophobic
aglycon, was marginally reactive, and 3) the reactivity of M9-MTX was markedly attenuated when it was conjugated with DHFR.
Isoflavone
aglycon and glucoconjugate content of high-and low-soy U.
Abeta(1-42) aggregates into non-toxic amyloid assemblies in the presence of the natural polyphenol oleuropein
aglycon.
Antioxidant and anti-inflammatory activities of anthocyanins and their
aglycon, cyanidin, from tart cherries.
The anthranoid compounds of Cascara are carried unabsorbed to the large intestine where the active
aglycon is released by bacterial hydrolysis of the sugar.
The stability depends on many factors, such as pH, temperature, and the nature of the
aglycon (15).
Indeed, Yoshino and Murakami [27] reported that both rutin and its
aglycon quercetin inhibited microsome peroxidation induced by Fe2+.
