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aging phenomenaGeriatrics The constellation of changes of aging
- Intrinsic aging
- The immutable effects of chronologic aging, eg atrophy-attenuation of epidermis, retration of rete pegs, ↓ number of Langerhans' cells and melanocytes, general decay of structural dermal and epidermal components
- Extrinsic aging
- Effects of external factors, eg sunlight, smoking, gravity and gravidity, keratinocytic dysplasia, solar elastosis, and possibly carcinogenesis; intrinsic & extrinsic aging are intimately linked and thus not subdivided