The typical clinical features of PLS include palmoplantar hyperkeratosis and generalized aggressive periodontitis
accompanied by severe alveolar bone destruction, leading to early loss of both primary and permanent dentitions.
(31.) Meng H, Ren X, Tian Y, Feng X, Xu L, Zhang L y colaboradores Genetic study of families affected with aggressive periodontitis
Microbiological criteria were not mentioned as primary features separating chronic from aggressive periodontitis
. However, for AgP, the secondary features that are generally, but not universally, present included elevated proportions of Aggregatibacter actinomycetemcomitan (AA) and, in some populations, Porphyromonas gingivalis (Pg), phagocyte abnormalities, and a hyper-responsive macrophage phenotype, including elevated levels of prostaglandin E2 and interleukin-1beta.
Klapproth et al., "The interleukin-10 promoter haplotype ATA is a putative risk factor for aggressive periodontitis
," Journal of Periodontal Research, vol.
Regarding aggressive periodontitis
, bacteria that play a role in periodontal disease are A.
Neutrophil-mediated tissue injury in periodontal disease pathogenesis: findings from localized aggressive periodontitis
. J Periodontal.
can be localised or generalised.