Platelet function was assessed using light transmission aggregometry
, VerifyNow PRUTest and vasodilator stimulated phosphoprotein assays.
Patients with suggestive history and screening tests were evaluated by Platelet Aggregometry
. Blood was drawn from a forearm venipuncture with minimal venous occlusion for platelet aggregation test.
We next investigated the platelet function by aggregometry
. In the ADP test (Table 2), all groups except for the MAN group showed a significant decrease in AUC when compared with the CON group.
Platelet Aggregation Testing.--Proficiency testing was provided for 2 types of platelet aggregation testing: optical aggregometry
and impedance aggregometry
Additionally, while the assessment of PA has been traditionally considered a limitation in itself, because classic platelet aggregometry
is difficult to perform, time-consuming, and prone to a variety of problems due to pre-analytical variables (8), whole-blood multiple electrode impedance platelet aggregometry
(MEA) is less complex and more reproducible (9).
Third, platelet reactivity was assessed with a sequential platelet counting method by PL-11, which has been demonstrated to be correlated with light transmittance aggregometry
and VerifyNow. Fourth, apart from platelet reactivity, other parameters such as MPV, platelet distribution width as well as platelet-large cell rate were not assessed in the present study.
Pre-analytical effects of pneumatic tube transport on impedance platelet aggregometry
. Platelets 2009;20:458-65.
The diagnosis occurred prematurely for the presence of frequent epistaxis, and the diagnosis was ascertained by light transmission aggregometry
One of the laboratory tests that help evaluate platelet function is aggregometry
, which measures the ability of some substances to induce in vitro platelet activation and aggregation.
Diagnosis should be suspected in patients with bleeding symptoms, and proper medical history, light transmission aggregometry
, platelet function analyser, and flow cytometry are remained as useful tools.
is the current gold standard for the diagnosis of platelet function disorders.
There are different PFT instruments which are widely used to assess antiplatelet drugs such as the optical light transmission aggregometry
(LTA) , the VerifyNow[R] system (VN) (Accumetrics Inc., San Diego, California) , the vasodilator stimulated phosphoprotein phosphorylation assay (VASP-P) [107, 108], the multiple electrode platelet aggregometry
(MEA) , the platelets function analyser (PFA-100) [109-111], the Impact-R assay , and the platelet-works[R] (PW) .