An instrument for measuring platelet aggregation by monitoring over time the changes in optic density of a platelet suspension treated with aggregating agents (ADP, collagen, epinephrine).
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Contract award notice: Consumables for the aggregometer
3] mol/l of Compound I into the aggregometer cuvet during 5 min of inductors makes platelet aggregation increase on average by 9.
Platelet reactivity ex vivo was assessed with a platelet-rich plasma (PRP) aggregometer using a ChronoLog after stimulating samples with collagen (2 [micro]g/ml), epinephrine (0.
Von Willebrand factor ristocetin cofactor (VWF: RCo) activity was measured with an in-house assay in a aggregometer (Chronolog Aggregometer 490) that measures the rate of aggregation of platelets in the presence of VWF and ristocetin.
Initially, the assay was performed using a platelet aggregometer, where ristocetin is added to a mixture of patient's plasma and formalin-fixed normal platelets.
5 mL platelet suspension and was determined using a computerized dual channel Chronolog Aggregometer (Chrono-Log Corporation, Havertown, PA) at 37[degrees]C as previously described [26].
Subsequently, in order to induce platelet aggregation, 25 [micro]L of an aqueous solution of 500 nM arachidonic acid (PAF) was added and induced aggregation was measured using an aggregometer (MCM Hema Tracer 313M, MC Medical Co.
Aggregation measurements obtained from LORCA aggregometer were based on the detection of laser backscattering from the sheared (disaggregated) and unsheared (aggregated) blood using a computer assisted system.
In delta granule disorders, the first wave in platalet aggregometer is normal, but there is second wave defect in aggregation with ADP, collagen, epinephrine and/or arachidonic acid in relation with deficiency of delta granules.
Measurement of platelet aggregation was done by the following procedure using the dual channel platelet aggregometer instrument by turbidometric method.
In this study platelet function analysis was performed using the Multiplate(R) platelet analyser (Dynabyte Munich Germany) a novel whole blood impedance aggregometer.