aggrecanase


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aggrecanase

(ag-gre'ka-nāz),
An enzyme found in cartilage that degrades extracellular matrix, especially cartilage.
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ADAMTS1, -4, -5, -8, -9 and -15 have aggrecanase activity whereas other members do not.
from Wyeth Pharmaceuticals outlined an unpublished study showing that in preclinical animal models aggrecanase activ ity is significantly increased immediately following injury, suggesting the potential for postsurgery aggrecanase inhibition "'to stop/slow down not only immediate cartilage degradation but also development of cartilage destruction in later years.
n-3 dose-dependently decreased the IL1-induced aggrecanase activity and basal aggrecanase and collagenase activity, whereas, in contrast, n-6 stimulated the basal aggrecanase and collagenase activity (74-77).
ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.
5) The inhibition of aggrecanase response was reported to be a consequence of metabolic changes that followed a marked increase in the intracellular glucosamine concentration, the exact mechanisms not yet being fully elucidated.
When stimulated there is an increase in cell expression in the chondrocytes of several matrix metalloproteinases (MMPs) such as MMP 1, 3 and 13, and prostaglandin E-2 (PGE-2), and aggrecanases such as a disintegrin and metalloproteinase with thrombospondin motif 4 (ADAMTS-4).
Hughes, "The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis," Arthritis Research and Therapy, vol.
Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro.
They discovered that these agents decreased interleukin-1-induced gene expression of several matrix metalloproteinases and aggrecanases involved in cartilage breakdown.
These include not only the production of metalloproteinases, collagenases, and aggrecanases that lead to cartilage breakdown in chondrocytes, but also the production of cytokines, such as interleukin-1 (IL-1), tumor necrosis factor (TNF), IL-6, IL-8, and nitric oxide (NO).