ACAN

(redirected from aggrecan core protein)

ACAN

A gene on chromosome 15q26.1 that encodes an aggrecan/versican proteoglycan, which is an integral part of the extracellular matrix in cartilage, where it provides compressive resistance.

Molecular pathology
ACAN mutations occur in skeletal dysplasia and spinal degeneration.
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References in periodicals archive ?
Both ADAMTSs and MMPs are able to degrade aggrecan [51-53]; however, ADAMTSs may be more efficient than MMPs with respect to the cleavage of the aggrecan core protein [54, 55].
The pCMV-HA control (control vector) and HA-tagged TPD52 and TPD54 overexpression vectors were transfected into ATDC5 cells, and the cells were subjected to DNA (a), GAG (b), ALPase activity (c), and Ca deposition (d) measurements, as well as RT-qPCR for type II collagen (e), aggrecan core protein (f), ALPase (g), and type X collagen (h).
(34) As discussed above, GAGs and their rich sulfate residues attach to the aggrecan core protein, thereby conveying a high net negative charge to the molecule that electrostatically binds water.