The measurement of the ACAN expression is due to the fact that aggrecan
is the predominant proteoglycan in articular cartilage, and its lost can also cause destruction of collagen network (ISHIGURO et al., 2002).
Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan
deposition in murine osteoarthritis models.
COMP is an abundant cartilage extracellular matrix protein that interacts with major cartilage components including aggrecan
Dauber, "Idiopathic short stature due to novel heterozygous mutation of the aggrecan
gene," Journal of Pediatric Endocrinology and Metabolism, vol.
(a, c) The expression of type II collagen, aggrecan
, Cytokeratin 8, MAP-1, MAP-2, and MAP-4 proteins noticeably decreased compared with that before loading.
Tenascin-R and CSPGs such as aggrecan
generally represent principal PNN components in the mature brain .
Interaction of cartilage oligomeric matrix protein/thrombospondin 5 with aggrecan
. J Biol Chem 2007;282:24591-8.
Studies of cartilage explants report decreases in the density of glycosaminoglycan within the proteoglycan molecule, decreases in aggrecan
molecule size and density, and increases in cartilage matrix degradation products such as low molecular weight hyaluronic acid and biglycan (25).
(22,23) Genetic transcription of chondrocytes increase the production of aggrecan
when influenced by mechanotransduction.
ADAMTS-1 is a MMP that has been implicated in the inhibition of angiogenesis induced by luteinizing hormone (LH) in the periovulatory follicles of the mouse and rat and is also thought to be a mediator of proteolytic cleavage of the hyaluronan binding proteoglycans, aggrecan
, and versican (16,17).
Salter, "Mechanotransduction via integrins and interleukin-4 results in altered aggrecan
and matrix metalloproteinase 3 gene expression in normal, but not osteoarthritic, human articular chondrocytes," Arthritis & Rheumatism, vol.
On the other hand, studies that evaluated immune responses towards different citrullinated proteins, such as citrullinated vimentin and citrullinated aggrecan
in RA patients, demonstrated a certain degree of immune cell stimulation directed to these citrullinated proteins [25, 26].