agglutinin


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Related to agglutinin: cold agglutinin

agglutinin

 [ah-gloo´tĭ-nin]
any substance causing agglutination (clumping together) of cells, particularly a specific antibody formed in the blood in response to the presence of an invading agent. Agglutinins are proteins (immunoglobulins) and function as part of the immune mechanism of the body. When the invading agents that bring about the production of agglutinins are bacteria, the agglutinins produced bring about agglutination of the bacterial cells.

Erythrocytes also may agglutinate when agglutinins are formed in response to the entrance of noncompatible blood cells into the bloodstream. A transfusion reaction is an example of the result of agglutination of blood cells brought about by agglutinins produced in the recipient's blood in response to incompatible or foreign cells (the donor's blood). Anti-Rh agglutinins are produced in cases of Rh incompatibility and can result in a condition known as erythroblastosis fetalis when the maternal blood is Rh negative and the fetal blood is Rh positive. (See also rh factor.)
cold agglutinin antibody that agglutinates erythrocytes or bacteria more efficiently at temperatures below 37°C than at 37°C.
group agglutinin one that has a specific action on certain organisms, but will agglutinate other species as well.
H agglutinin one that is specific for flagellar antigens of the motile strain of an organism.
immune agglutinin a specific agglutinin found in the blood after recovery from the disease or injection of the microorganism.
incomplete agglutinin one that at appropriate concentrations fails to agglutinate the homologous antigen.
O agglutinin one specific for somatic antigens of a microorganism.
platelet agglutinin an antibody capable of agglutinating platelets; these may be associated with a variety of disorders, with and without frank thrombocytopenia.
warm agglutinin an incomplete antibody that sensitizes and reacts optimally with erythrocytes at 37°C.

ag·glu·ti·nin

(ă-glū'ti-nin),
1. An antibody that causes clumping or agglutination of the bacteria or other cells that either stimulated the formation of the agglutinin, or contain immunologically similar, reactive antigen. Synonym(s): agglutinating antibody, immune agglutinin
2. A substance, other than a specific agglutinating antibody, that causes organic particles to agglutinate, for example, plant agglutinin.

agglutinin

(ə-glo͞ot′n-ĭn)
n.
A substance, such as an antibody, that is capable of causing agglutination of a particular antigen, especially red blood cells or bacteria.

Agglutinin

Medspeak Any antigenic substance capable of agglutinating. See Neuroprotective agglutinin, 2-adrenoceptor agglutinin, Cold agglutinin, Febrile agglutinin, Mixed fieldagglutinin.

ag·glu·ti·nin

(ă-glū'ti-nin)
1. An antibody that causes clumping or agglutination of the bacteria or other cells that either stimulated the formation of the agglutinin or contain immunologically similar, reactive antigen.
2. A substance, other than a specific agglutinating antibody, that causes organic particles to agglutinate.

agglutinin

A substance that causes cells or other particles to clump together and, usually, to lose their former properties. ‘Warm’ agglutinins function at normal body temperatures; ‘cold’ agglutinins do so at lower temperatures. Agglutinins can cause severe ANAEMIA.

Agglutinin

An antibody that causes particulate antigens such as bacteria or other cells to clump together.

ag·glu·ti·nin

(ă-glū'ti-nin)
Antibody that causes clumping or agglutination of the bacteria or other cells that either stimulated the formation of the agglutinin or contain immunologically similar, reactive antigen.
References in periodicals archive ?
Serum anti-RSV IgM 0.64 Serum anti-RSV IgG 1.4 Nasal influenza A/B swab Negative Anti-ribosomal P antibody Negative Anti-nuclear antibody Negative Anti-DNA antibody Negative Smooth muscle antibody Negative Anti-scleroderma 70 antibody Negative Myeloperoxidase Negative Proteinase 3 antibody Negative Cold agglutinin antibody Negative Rheumatoid factor Negative Anti-cyclic citrullinated antibody Negative HIV Negative Chlamydiapneumoniae IgM <1:20 Chlamydial pneumonia IgG <1:64 Legionella antigen, urine Negative Histoplasma antigen, urine Negative Blood, urine, and respiratory culture Negative BAL cultures and acid fast bacilli stains Negative Cryoglobulin level Negative M.
Vojdani, "Immune reactivities to peanut proteins, agglutinins, and oleosins," Alternative Therapies in Health and Medicine, vol.
[139] showed that the covalent surface modification of microparticles containing a gemcitabine derivative with wheat germ agglutinin (WGA) resulted in enhancing of binding duration on urothelial cells; bound microparticles were able to withstand the extensive washout and improved antiproliferative activity [139].
In our study, the Tn antigen recognizing lectins, Helixpomatia agglutinin and VVL did not bind to OvCa-CA125, indicating that in OvCa-MGL was not binding to Tn-antigen but likely to sialyl Tn antigen or the LacdiNAc.
Comparison of mucus and epithelial cells by wheat germ agglutinin (WGA) staining in the gills of freshly sampled, long-term cultivated Calyptogena okutanii
Abbreviations: RIP(s), ribosome inactivating protein(s); HU, hemagglutination unit; ECA, Euphorbia calcina agglutinin; EDA, Euphorbia dalberi agglutinin; EspA, Euphorbia sp.
Tissue specific expression of potent insecticidal, Allium sativum leaf agglutinin (ASAL) in important pulse crop, chickpea (Cicer arietinum L.) to resist the phloem feeding Aphis craccivora.
Further extensive studies excluded immunological and infectious causes of RBC destruction, and cold agglutinin were negative.
The cells were labeled with 0.1gg/ml Hoechst 33342, 100nM Mitotracker red and 1mg/ml wheat germ agglutinin conjugated to TRITC (WGA--TRITC) to visualize nuclei, mitochondria, and plasma membrane respectively.
Then slides incubated with Ulex europaeus agglutinin (UEA-I) and peanut agglutinin (PNA) peroxidase conjugated lectins at room temperature for 2 hr, were washed in PBS solution for 20-30 min, then placed in DAB-[H.sub.2][O.sub.2] (diaminobenzidine) for 5-10 min.
Particles of an antigen will only clump together in the presence of the specific agglutinin to that antigen.
Q When preheating a specimen with a severe cold agglutinin does not work (i.e., MCHC remains > 37.0), what is the best way to tackle this problem?