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Loss of taste sensation is a rare side effect of terbinafine that occurs in 0.6 to 2.8 percent of those taking this drug.3 The mechanism of terbinafine-induced ageusia remains unclear.
Como secuelas presento convulsiones tonico-clonicas generalizadas, alteraciones de la memoria, desorientacion, heteroagresion severa (hasta llegar a asesinar animales), alteraciones del comportamiento (mutismo, automatismos), cefalea frontotemporal, diplopia, hiposmia, ageusia, delirios persecutorios, alucinaciones visuales y auditivas.
There are some specific names for the dysfunctions, including ageusia (absence of taste), hypogeusia (diminished sensitivity of taste), dysgeusia (distortion of normal taste), hyposmia (distortion of normal smell) and others.
Patients may experience ageusia (absence, partial loss, or impairment of the sense of taste) or dysgeusia (impairment or perversion of the gustatory sense such that normal tastes are interpreted as being unpleasant or completely different from the characteristic taste of a particular food or chemical compound) (Ganley, 1995; Little, 1996).
Loss of taste, also known as ageusia, and loss of smell, also known as anosmia, have traditionally been thought of as conditions primarily suffered by smokers and snuff users.
Some people can detect no odors (anosmia) or no tastes (ageusia).
Penicillamine and captopril, both containing a sulfhydryl group, have been implicated in ageusia.[7] Ageusia has also been associated with transdermal nitroglycerin.[8] Tetracycline and metronidazole have been associated with a metallic taste.[9,10] Dysgeusia secondary to acetazolamide therapy has previously been described only once in the English language literature.[6]
Devido a interrelacao entre olfato e paladar, laringectomizados totais podem apresentar ageusia ou hipogeusia.
The operative factors that may lead to a lack of (ageusia) or altered (dysgeusia) taste are controversial.
Referred to as ageusia, the disorder can also happen due to a cause ranging from head or facial injury, certain medications, tooth decay or poor dental hygiene and smoking.
As lesoes centrais que envolvem vias gustativas parecem gerar desordens quantitativas (ageusia ou hipogeusia), em contraste com as lesoes perifericas, que parecem gerar desordens qualitativas (disgeusia) [14].