aganglionosis, agangliosis

congenital absence of parasympathetic ganglion cells.

colonic aganglionosis
congenital defect manifested by stenosis, but patency, of the colon, an absence of ganglia of the myenteric plexus and an almost complete absence of skin pigment in white foals resulting from matings between overo horses. The foal develops colic at birth and dies after about 48 hours. See also atresia. Occurs also in some spotted mutant strains of mice. Called also congenital megacolon, aganglionic megacolon.
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References in periodicals archive ?
HD is one of the most common causes of intestinal obstruction in newborn, being caused by the agangliosis of the bowel, from the internal anal sphincter to a variable distance proximally, most frequently affecting the rectosigmoid region.
Moreover, the clinical presentation can be directly influenced by the complications arising in HD's evolution, among which enterocolitis is considered to be multifactorial, mainly based on the connection between the agangliosis characterizing Hirschsprung disease, defective intestinal barrier and influence of altered commensal microflora [7, 8].
However, family's compliance regarding daily colon evacuation and also the presence of a rectosigmoid agangliosis, not of a pancolic involvement, contributed to a favorable evolution.