afterload

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afterload

 [af´ter-lōd]
the tension developed by the heart during contraction; it is an important determinant of myocardial energy consumption, as it represents the resistance against which the ventricle must pump and indicates how much effort the ventricles must put forth to force blood into the systemic circulation. Factors that increase afterload include aortic and pulmonarystenosis, systemic and pulmonary hypertension, and high peripheral resistance.

af·ter·load

(af'ter-lōd),
1. The arrangement of a muscle so that, in shortening, it lifts a weight from an adjustable support or otherwise does work against a constant opposing force to which it is not exposed at rest.
2. The load or force thus encountered in shortening.

afterload

/af·ter·load/ (-lōd″) the force against which cardiac muscle shortens: in isolated muscle, the force resisting shortening after the muscle is stimulated to contract; in the intact heart, the pressure against which the ventricle ejects blood.

afterload

Etymology: AS, aefter + ME lod
the load, or resistance, against which the left ventricle must eject its volume of blood during contraction. The resistance is produced by the volume of blood already in the vascular system and by the constriction of the vessel walls.

Afterload

Cardiology The amount of haemodynamic pressure (peripheral vascular resistance) downstream from the heart, which increased in heart failure secondary to aortic stenosis and hypertension. Cf Preload.
Physiology The tension produced by heart muscle after contraction.

afterload

Cardiology The amount of hemodynamic pressure–peripheral vascular resistance downstream from the heart–which ↑ in heart failure 2º to aortic stenosis and HTN. Cf Preload Physiology The tension produced by heart muscle after contraction.

af·ter·load

, after-load (af'tĕr-lōd)
1. The arrangement of a muscle so that, in shortening, it creates a force from an adjustable support or otherwise work against an opposing force to which it is not exposed at rest.
2. The load or force thus encountered in shortening.
3. That resistance against which the left ventricle must eject its volume of blood during contraction.

afterload

see cardiac afterload.
References in periodicals archive ?
LV dysfunction can occur in ASO due to two reasons firstly because of overfilling or increase in after-load and secondly due to myocardial ischaemia secondary to reduced or obstructed flow through re-implanted coronaries.
The mechanism for hypotension and shock in sepsis are: reduced pre-load, myocardial suppression as well as reduced after-load contributing to hyperdynamic but insufficient cardiac function resulting in tachycardia and hypotension.
In healthy, young, populations, after-load may not be a major determinant in altering SV, because after-load is dependent on aortic elasticity, which under normal circumstances should not be compromised since aortic compliance and cross sectional area increases with increasing pressures.
A useful way of describing the problem is to consider the patient's journey, using the analogy of the cardiac cycle and the concepts of pre-load, contractility and after-load.
Desflurane has been found to decrease arterial pressure in a dose-related manner by decreasing peripheral resistance and reducing after-load (1).
A second mechanism of action involves the opening of ATP-dependent potassium channels in vascular smooth muscle, resulting in reduced preload and after-load due to arterial and venous dilation, Dr.
Clinician can use this new technology to more rapidly assess the effects of treatment on cardiac function, for example, after-load reduction, or as a means to quantify valvular regurgitation.