Interestingly, if we look at the diverging correlation of AvIgG and AvIgE with specific IgE, we can also postulate that avidity is not only the outcome of an
affinity maturation process of antibodies within an antibody isotype, but also the outcome of a mechanism, in which probably outcompeting of an immunoglobulin isotype over another could have been resulted by high-affinity antibodies in the maturation process [30].
A hybrid between genetic algorithms and artificial immune system method has been proposed that takes into account the main immune aspects: selection and cloning of the most stimulated cells, death of non- stimulated cells,
affinity maturation and re-selection of the clones with higher affinity, generation and maintenance of diversity, hypermutation proportional to the cell affinity.
Improvement of a recombinant anti-monkey anti-CD3 diphtheria toxin based immunotoxin by yeast display
affinity maturation of the scFv.
The improvement in homotypic neutralizing antibody titer and decrease in heterotypic neutralizing antibody titer described here is reminiscent of
affinity maturation. However, long-lived plasma cells would not be expected to participate in the selection process required for
affinity maturation.
The Xenerex system is able to take advantage of the unique in vivo cellular interactions, which occur in the human immune system that result in natural
affinity maturation. This is the process by which the immune system generates antibodies of high specificity and affinity.
The combination of Abgenix's high throughput selection technologyM and Abgenix's XenoMouse takes advantage of the natural in vivo
affinity maturation process and the maintenance of the original heavy and light chain pairs.
