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Affinity MaturationThe increased average affinity of antibodies to an antigen, which follows immunisation. Affinity maturation results from an increase of specific and more homogeneous IgG antibodies, and follows a less specific and more heterogeneous early response by IgM molecules.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
The mechanism during an immune response that produces antibodies with a strong ability to bind to a foreign antigen over time. Affinity maturation is produced by changes in the genes that encode immunoglobulin G (IgG) and by increased survival of those B lymphocytes that produce antibodies with the greatest ability to destroy a particular antigen. Increased affinity occurs only when B-cell activation is stimulated by helper T cells.
See also: maturation
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