The title of the fifth order, To mega chasma (The Great Chasm), seems at first to refer to the gap of time between the present and the Grecian past, for two of the four elements of the cycle (Hagiographia  and Epidaurus [n.d.]) depict the ruins of the Byzantine city of Mistra and the Aesculapian
clinic of Epidaurus.
During the 1960s a female aesculapian
snake was brought to Colwyn Bay as an intended exhibit.
The spine becomes an Aesculapian
staff wound by contrary forces: "around [the spine] .
In 1834 Graham published a whole book of case histories, pompously entitled The Aesculapian
Tablets of the Nineteenth Century, in which grateful patients revealed how a vegetable diet had saved them from frightful maladies.
Rumours abounded the aesculapian
rat snake had slipped out of Colwyn Bay Mountain Zoo, and was breeding in the wild.
In addition, the valleys are home to some snakes, especially Dromicus angustilineaus, which is reminiscent of the Aesculapian
snake (Elaphe longissima) from Europe, and Tachymenis peruviana, which resembles a European terrestrial smooth snake (Coronella).