aequorin


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ae·quo·rin

(ē'kwō-rin),
A luminescent protein isolated from the jellyfish Aequorea that emits blue light in the presence of even minute amounts of calcium ion; injected intracellularly, it is used to measure free calcium ion transients within cells.
See also: fura-2, quin-2.

aequorin

(ē-kwôr′ĭn, ē-kwŏr′-)
n.
A protein secreted by certain bioluminescent jellyfish, used as a reagent in molecular biology to detect calcium concentrations inside cells.

ae·quo·rin

(ē-kwōr'in)
A luminescent protein isolated from the jellyfish Aequorea, which emits blue light in the presence of even minute amounts of calcium ion; injected intracellularly, it is used to measure free calcium ion transients within cells.
See also: fura-2
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References in periodicals archive ?
Aequorin technology, based on a naturally occurring photoprotein, generates large, luminescent signals that result in higher quality data, while reducing the number of false positives in high throughput and ultra-high throughput screening environments.
Aequorin glows blue when calcium ions bind to it, but it's more than just a pretty protein.
"One of the reasons that we're pursuing a modified Tetra is that we find that the current suppliers of readers for aequorin don't have the preferred features that our customers want.
This discovery led to the use of aequorin as an important biomedical tool for tracking the movement of calcium within cells.
The observations may also be relevant in explaining the efficient energy transfer between aequorin and GFP in the light-emitting organ of the jellyfish itself.
The output of this model (mentioned above) evokes a calcium signal detectable with high sensitivity aequorin (e.g., 4-6) within 250 [micro]s of the start of [PLA.sub.2] activity, assuming a single calcium ion is released per [LtB.sub.4] produced.
In the class Hydrozoa, all reported cases of luminescence are caused by [Ca.sup.2+]-sensitive photoproteins such as aequorin, found in the jellyfish Aequorea aequorea (Shimomura et al., 1962), and obelin, obtained from the hydroid Obelia sp.
The blastomeres were injected with 10-pl doses of semisynthetic aequorin (17-19) shortly after the first cytokinesis following fertilization.
Extraction of Renilla-type luciferin from the calcium-activated photoproteins aequorin, mnemiopsin and berovin.
Individual calcium release events were visualized as bright observable blobs in aequorin labeled cells (6, 7) and they occur within restricted regions of space called microdomains (6, 7).