adverse drug reactions


Also found in: Encyclopedia.

adverse drug reactions

; ADRs un-intended and harmful effect of drug therapy, neither intended nor expected in normal therapeutic use (Table 1)
Table 1: Types of adverse drug reaction
TypeFeatures
ACommon, dose-related, predictable, augmented drug effect in patients showing excessive response to normal drug dosage; managed by dose reduction
BBizarre, rare, unpredictable, non-dose-related, immunological-based, severe drug reaction; drug must be withdrawn immediately
CGradual reduction of drug effectiveness over time; due to adaptation/habituation
DDelayed effects of drug
EEnd-of-use withdrawal reaction
FUnexpected failure of therapeutic effect, possibly due to interaction with another drug
References in periodicals archive ?
Abu Dhabi: The Ministry of Health and other health authorities are in the process of establishing a national pharmaco-vigilance programme to deal with adverse drug reactions and medication errors.
and TheraDoc of Salt Lake City, a pilot at five VA medical centers in Texas, Missouri and Illinois will use clinical and laboratory data in real time to identify patients at risk of adverse drug reactions and reduce medical complications.
Frequency and nature of adverse drug reactions in elderly inpatients of two Indian medical college hospitals.
As per the Naranjo Adverse Drug Reaction Probability Scale,[sup][4] this case can able to answer for only one positive correlation “Did the adverse event appear after the suspected drug was administered” with a final score of 2 (1–4 = possible adverse drug reaction [ADR]) making possible ADR only.
According to statistics for 2013-2015, antibiotics were responsible for 47 per cent of adverse drug reactions in the emirate.
The definition of adverse drug reactions as given by WHO is 'any response to a drug which is noxious and unintended and which occurs at doses, normally used for prophylaxis or diagnosis or therapy or disease or for modification of physiological function'.
The most effective way to minimise adverse drug reactions in women is to develop and implement sex-specific guidelines for cardiovascular drugs, the authors concluded.
Secondly, although this review summarizes major adverse drug reactions related to PPIs, one of an important adverse drug reaction has been neglected.
Adverse drug reactions & their risk factors among Indian ambulatory elderly patients.
This is because the recent epidemiological studies have estimated that adverse drug reactions are the fourth to sixth leading causes of death and that they represent 5% to 10% of the hospital costs.
The WISH webinar highlighted the significant clinical and economic impact of adverse drug reactions as participants outlined examples of drugs that cause such reactions and ways to mitigate them.
Despite the effort of National and International authorities to stimulate the notification of Adverse Drug Reactions (ADRs), under-reporting is still quite common (3).

Full browser ?