advanced glycation endproducts


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advanced glycation endproducts

; AGEs formation of endproducts of non-enzymatic protein lipoproteins and nucleic acid glycosylation; exaggerated in old age, but accelerated in poorly controlled diabetes mellitus; AGEs accumulate in structural proteins (of ligaments, blood vessel walls, etc.) to compromise the microcirculation, especially within skin, vasa vasorum and vasa nervosum, contributing to the secondary complications of long-term diabetes, i.e. loss of joint mobility, neuropathy and ischaemia (see glycosylated haemoglobin; glycosylation)
References in periodicals archive ?
Advanced glycation endproducts (AGEs) in diabetic patients with systemic lupus erythematosus.
Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension.
Advanced glycation endproduct crosslinking in the cardiovascular system: potential therapeutic target for cardiovascular disease.
It has been shown that advanced glycation endproducts, which have formed as a result of hyperglycemia/hyperlipidemia, can alter the phenotype of cell types by receptor advanced glycation endproducts, a cell surface receptor.
Advanced glycation endproducts have also been reported on lipids, nucleic acids, and short-lived serum proteins.
This upregulation is due to a number of parameters that are present in the diabetic milieu, including hyperglycemia, an activated renin angiotensin aldosterone system, advanced glycation endproducts, and oxidized lipids.
Targeting advanced glycation endproducts and mitochondrial dysfunction in cardiovascular disease.
Arendt, Comparison of Results of the Celltiter Blue, the Tetrazolium (3-[4,5-dimethylthioazol- 2-yl]-2,5-diphenyl tetrazolium bromide), and the Lactate Dehydrogenase Assay Applied in Brain Cells After Exposure to Advanced Glycation Endproducts, Toxicol.
Smit, "Skin autofluorescence, as marker of accumulation of advanced glycation endproducts and of cumulative metabolic stress, is not increased in patients with systemic sclerosis," International Journal of Rheumatology, vol.
Smit, "The clinical relevance of assessing advanced glycation endproducts accumulation in diabetes," Cardiovascular Diabetology, vol.
RAGE, or receptor for advanced glycation endproducts, proteins bind to amyloid and transport it into the brain," said Scott Webster, a fifth-year graduate student who is studying the disease in the lab of Dr.
Scout DS measures skin fluorescence using proprietary technology to detect abnormal concentrations of advanced glycation endproducts (AGEs) which are diabetes-related biological markers found in skin.

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