In addition to pain alleviation, preclinical work on NB-01 has demonstrated effects on increasing the release of nerve growth factor, stimulating nerve growth, and inhibiting
advanced glycation end-products and inflammatory markers.
These harmful byproducts are called
advanced glycation end-products (AGEs).
Receptor for
advanced glycation end-products (RAGE) and soluble RAGE (sRAGE): Cardiovascular implications.
Glycation is the body's natural process where sugar molecules bind with fat and protein molecules to form
Advanced Glycation End-products (or AGEs).
The immunobiology of the receptor of
advanced glycation end-products: trends and challenges.
Under the hyperglycolytic conditions, for example, the proteins experience nonenzymatic posttranslational modification leading the formation of
advanced glycation end-products (AGEs).
Gajda et al., "Vascular effects of
advanced glycation end-products: content of immunohistochemically detected AGEs in radial artery samples as a predictor for arterial calcification and cardiovascular risk in asymptomatic patients with chronic kidney disease," Disease Markers, vol.
Hirabayashi et al., "Receptor for
advanced glycation end-products is a marker of type I lung alveolar cells," Genes to Cells, vol.
Zeni et al., "The receptor for
advanced glycation end-products (RAGE) is only present in mammals, and belongs to a family of cell adhesion molecules (CAMs)," PLoS One, vol.
- AGEs Sensor simply and easily measures the level of accumulated AGEs (
advanced glycation end-products)
Mechanisms of disease:
advanced glycation end-products and their receptor in inflammation and diabetes complications.
Kampus et al., "Vitamin D reduces deposition of
advanced glycation end-products in the aortic wall and systemic oxidative stress in diabetic rats," Diabetes Research and Clinical Practice, vol.