Chemotherapy for
advanced gastric cancer. Cochrane Database Syst Rev 2010; 17: CD004064.
To the best of our knowledge, few studies of ERAS focus on patients with locally
advanced gastric cancer who are administered neoadjuvant chemotherapy.
Wang et al., "Does a higher cutoff value of lymph node retrieval substantially improve survival in patients with
advanced gastric cancer?--Time to embrace a new digit," The Oncologist, vol.
e, "HER2-positive
advanced gastric cancer:similar HER2-positivity levels to breast cancer," European Journal of Cancer, vol.
In conclusion, some progress has been reached in the treatment of
advanced gastric cancer in the last years.
Hejna, "Palliative chemotherapy for
advanced gastric cancer," Annals of Oncology, vol.
The prognostic significance of HER2 positivity for
advanced gastric cancer patients undergoing first-line modified FOLFOX-6 regimen.
Laura added: "Immunotherapy is available here on the NHS but has only been approved for certain cancers and has not been approved for stomach cancer, despite evidence showing it has the potential to increase life expectancy dramatically in
advanced gastric cancer compared to chemotherapy.
However, even after potentially curative resection with satisfactory safety margins, the prognosis of patients with locally
advanced gastric cancer is still worrying.
The Japanese Gastric Cancer Association (7) recommended simultaneous splenectomy during total gastrectomy to facilitate removal of splenic hilar lymph nodes in
advanced gastric cancer involving the upper third of the stomach.
These two trials emphasize the efficacy of preoperative chemotherapy in
advanced gastric cancer, suggesting a new direction in the treatment of AGC.
Combinations of surgery, chemotherapy, and radiotherapy are common treatment options for
advanced gastric cancer, but the prognosis is always poor [4, 5].