Adrenotensin | definition of adrenotensin by Medical dictionary
adrenotensin A polypeptide hormone which is derived from the same propeptide precursor as its more extensively studied sibling, adrenomedullin. Both act as circulating hormones and local paracrine mediators with multiple biological activities. Increased levels of angiotensin II and angiotensin II type-1 receptor after adrenotensin treatment mediate angiotensin’s stimulating effects on cell proliferation and extracellular matrix synthesis and secretion.
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References in periodicals archive
It has also been hypothesized that another biologically active peptide adrenotensin may also be product of adrenomedullin gene.
Lippton, "Adrenotensin: an ADM gene product with the opposite effects of ADM" Life Sciences, vol.
Among them, ADM and adrenotensin (ADT) are distributed throughout the vascular smooth
Effect of adrenotensin on cell proliferation is mediated by angiotensin II in cultured rat mesangial cells.
In a study comparing different ADM gene-derived peptides (16), MR-proADM had no physiologic effect, whereas all other peptides (ADM, PAMP, and adrenotensin
) exhibited activity.