adrenomedullin


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adrenomedullin

A peptide produced by vascular endothelium and the adrenal medulla; in experimental animal studies, it exerts a long-lasting hypotensive effect associated with reduced vascular resistance and inhibition of aldosterone secretion from the zona glomerulosa of the adrenal cortex.
[adreno- + medulla + -in]

Adrenomedullin

Either of two (AM1, AM2) widely expressed peptides encoded by ADM on chromosome 11p15.4, which is thought to function as a hormone in the peripheral circulation.
Physiologic functions AM (AM2 is less well studied) is a potent vasodilator and involved in a broad range of physiologic activities including control of fluid and electrolyte homeostasis. In the kidney, it is diuretic and natriuretic, and inhibits aldosterone secretion by direct antagonism. AM inhibits basal ACTH secretion in the pituitary and brain, where it facilitates loss of plasma volume, thus complementing its hypotensive effect on peripheral vessels. It is involved in angiogenesis and increases cell tolerance of oxidative stress and hypoxic injury.
Angiogenesis AM has a positive impact on hypertension, myocardial infarction, and COPD.
Cognate receptors Calcitonin receptor like receptor (CALCRL), receptor activity-modifying proteins (RAMP2), and complexes, as well as calcitonin gene related peptide (CGRP) receptor.

adrenomedullin

(ă-drē″nō-mĕ-dŭl′ĭn) [ adreno- + medullin, a renal prostaglandin],

AM

A 52–amino acid regulatory peptide that influences many body functions. These functions include blood vessel dilation (lowering blood pressure), cellular growth, circulation, electrolyte balance, kidney function, and neurotransmission. The level of adrenomedullin in the blood is elevated above normal in patients with congestive heart failure, kidney failure, and diabetes mellitus complicated by vascular disease.
References in periodicals archive ?
Unsworth et al., "Complement factor H is a serum binding protein for adrenomedullin, and the resulting complex modulates the bioactivities of both partners," The Journal of Biological Chemistry, vol.
Wang, "Adrenomedullin and adrenomedullin binding protein-1 downregulate TNF-[alpha] in macrophage cell line and rat Kupffer cells," Regulatory Peptides, vol.
Hatakeyama et al., "Antifibrotic effect of adrenomedullin on coronary adventitia in angiotensin II-induced hypertensive rats," Cardiovascular Research, vol.
Distribution and characterization of immunoreactive rat adrenomedullin in tissue and plasma.
Effect of static handgrip on plasma adrenomedullin concentration in patients with heart failure and in healthy subjects.
Although the physiological role of EAT on vessels is not entirely clear, it has been shown that epicardial adipocyte through the secretion of adiponectin and adrenomedullin exerts anti-inflammatory, antiatherogenic, and even antidiabetic effects in coronary arteries [96, 97], participating in the regulation of the diameter on the vessel wall.
(2011) Adrenomedullin: A possible regulator of germinal vesicle breakdown.
These biomarkers include MR-proADM (midregional pro adrenomedullin), MR-proANP (midregional pro atrial natriuretic peptide) and CT-proET1 (C-terminal pro endothelin-1).
Production of adrenocorticotropic hormone, [beta]-endorphin, corticotropin-releasing hormone, calcitonin gene-related peptide, vasoactive intestinal peptide, growth hormone-releasing hormone, neuropeptide Y, peptide YY, insulin-like growth factor-1, galanin, adrenomedullin, serotonin, somatostatin, and gastrinlike neuropeptide have been reported.
Zhao, "Effects of adrenomedullin gene overexpression on biological behavior of hepatic stellate cells," World Journal of Gastroenterology, vol.
Several families of antimicrobial peptides have been identified in oral cavity which includes [alpha]-defensins, [beta]-defensins, calprotectin, adrenomedullin, histatins, and cathelicidin.