adrenomedullin


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adrenomedullin

A peptide produced by vascular endothelium and the adrenal medulla; in experimental animal studies, it exerts a long-lasting hypotensive effect associated with reduced vascular resistance and inhibition of aldosterone secretion from the zona glomerulosa of the adrenal cortex.
[adreno- + medulla + -in]

Adrenomedullin

Either of two (AM1, AM2) widely expressed peptides encoded by ADM on chromosome 11p15.4, which is thought to function as a hormone in the peripheral circulation.
Physiologic functions AM (AM2 is less well studied) is a potent vasodilator and involved in a broad range of physiologic activities including control of fluid and electrolyte homeostasis. In the kidney, it is diuretic and natriuretic, and inhibits aldosterone secretion by direct antagonism. AM inhibits basal ACTH secretion in the pituitary and brain, where it facilitates loss of plasma volume, thus complementing its hypotensive effect on peripheral vessels. It is involved in angiogenesis and increases cell tolerance of oxidative stress and hypoxic injury.
Angiogenesis AM has a positive impact on hypertension, myocardial infarction, and COPD.
Cognate receptors Calcitonin receptor like receptor (CALCRL), receptor activity-modifying proteins (RAMP2), and complexes, as well as calcitonin gene related peptide (CGRP) receptor.

adrenomedullin

(ă-drē″nō-mĕ-dŭl′ĭn) [ adreno- + medullin, a renal prostaglandin],

AM

A 52–amino acid regulatory peptide that influences many body functions. These functions include blood vessel dilation (lowering blood pressure), cellular growth, circulation, electrolyte balance, kidney function, and neurotransmission. The level of adrenomedullin in the blood is elevated above normal in patients with congestive heart failure, kidney failure, and diabetes mellitus complicated by vascular disease.
References in periodicals archive ?
Effects of acute restraint stress on endogeneous adrenomedullin levels.
Eto, "Distribution and characterization of immunoreactive adrenomedullin in human tissue and plasma," FEBS Letters, vol.
Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology.
Progesterone receptor modulator CDB-2914 down-regulates vascular endothelial growth factor, adrenomedullin and their receptors and modulates progesterone receptor content in cultured human uterine leiomyoma cells," Human Reproduction 21 (9): 2408-2416.
Adrenomedullin (ADM) is a potent vasodilatory peptide expressed in multiple tissues including the heart.
Adrenomedullin in the kidney: physiology and pathophysiology.
Impact of adrenomedullin on dextran sulfate sodium-induced inflammatory colitis in mice: insights from in vitro and in vivo experimental studies," International Journal of Colorectal Disease, vol.
21) evaluated uterine PI and plasma adrenomedullin (AM) levels in women with unexplained recurrent pregnancy loss (RPL) compared to controls and found that uterine artery PI and AM levels were significantly higher in RPL group.
Targeting adrenomedullin receptors with systemic delivery of neutralizing antibodies inhibits tumor angiogenesis and suppresses growth of human tumor xenografts in mice.
Adrenomedullin normal fizyolojik sartlarda dolasimin duzenlenmesinde onemli duzenleyici rol oynadigi dusunulen bir peptiddir (2).