adrenogenital syndrome


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Related to adrenogenital syndrome: Androgen insensitivity syndrome

adrenogenital syndrome

 [ah-dre″no-jen´ĭ-t'l]
a group of symptoms associated with alterations of secondary sex characters, due to abnormally increased production of androgens by the adrenal glands. The term most commonly applies to the development of masculine traits in the female or premature puberty in male children. The condition may be congenital, in which case it is due to an inherited defect of the adrenal gland, or acquired, developing as a result of a tumor or hyperplasia of the adrenals.
Symptoms. Females with the congenital form may be reared as boys because of masculinization of the external genitalia. Males may show sexual precocity, with development of the reproductive organs, appearance of pubic hair, and excessive body growth in early childhood. In acquired adrenogenital syndrome there is appearance of masculine secondary sex characters in the female, and precocious puberty in the male.
Treatment. When an adrenal tumor is the underlying cause of the disorder, it is removed surgically. Estrogen therapy is successful in some cases.

a·dre·no·gen·i·tal syn·drome

generic designation for a group of disorders caused by congenital adrenocortical hyperplasia characterized by masculinization of women, feminization of men, sexual ambiguity or precocious sexual development of children; representative of excessive or abnormal secretory patterns of adrenocortical steroids, especially those with androgenic or estrogenic effects.

adrenogenital syndrome

Congenital adrenal hyperplasia, see there.

ad·re·no·gen·i·tal syn·drome

(ă-drē'nō-jen'i-tal sin'drōm)
Generic designation for a group of disorders caused by adrenocortical hyperplasia or malignant tumors and characterized by masculinization of women, feminization of men, or precocious sexual development of children; representative of excessive or abnormal secretory patterns of adrenocortical steroids, especially those with androgenic or estrogenic effects.

adrenogenital syndrome

Now called congenital adrenal hyperplasia, this condition is due to various inherited enzyme defects, such as 21-hydroxylase defect, that interfere with the production of STEROIDS by the adrenals. The low blood steroid levels causes the PITUITARY gland to send out large quantities of the adrenal stimulating hormone ACTH and this results in an abnormally high output of male sex hormones, with virilization at birth and male sexual precocity.

ad·re·no·gen·i·tal syn·drome

(ă-drē'nō-jen'i-tal sin'drōm)
Group of disorders caused by congenital adrenocortical hyperplasia characterized by masculinization of women, feminization of men, and sexual ambiguity or precocious sexual development of children.
References in periodicals archive ?
Clinical disorder Presumed pathogenesis References Adolescent Advanced bone maturation by [1, 5, 6] hyperthyroidism toxic hormone doses Exposure to corticoids Complex findings in vitro; [7,16,17,19] extensive research in earlier decades; direct influence on cartilage matrix Adrenogenital syndrome Unknown [8, 9] Keutel syndrome Autosomal recessive disorder [10,11] with several anomalies; frequent consanguinity, description, 1971 Mutations in the matrix [24] Gla protein gene (MGP) that acts as a calcification inhibitor (for details see [24]) Porphyria Unknown This paper Systemic conditions as Unknown [1] chronic renal failure or autoimmune disorders
Adrenal myelolipoma, which is a nonfunctional tumor, may be found coincidentally in patients affected by Cushing's syndrome, hyperaldosteronism, pheochromocytoma, adrenogenital syndrome, and virilization (3,4,5).
Conventional LCT (ie, tumors in which the cells are round to polygonal with eosinophilic cytoplasm, arranged in sheets, nests, or trabecula) must be differentiated from Leydig cell hyperplasia, granular cell tumor, malakoplakia, the testicular nodules of adrenogenital syndrome, and other tumors of the testis (Table).