Also found in: Dictionary, Thesaurus, Encyclopedia.
Related to adrenocorticotropin: aldosterone, emedullate, hypomastia


1. a hormone secreted by the anterior lobe of the pituitary gland that stimulates the cortex of the adrenal gland to secrete its hormones, including corticosterone. If production of corticotropin falls below normal, the adrenal cortex decreases in size, and production of the cortical hormones declines.
2. a pharmaceutical preparation of animal-derived corticotropin, administered intravenously for diagnostic testing of adrenocortical function and subcutaneously or intramuscularly, in a slowly absorbed gel form (repository corticotropin), as an anticonvulsant for treating infantile spasms. Called also adrenocorticotropic hormone (ACTH), adrenocorticotropin, and corticotrophin.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

a·dre·no·cor·ti·co·tro·pic hor·mone (ACTH),

the hormone of the anterior lobe of the hypophysis that governs the nutrition and growth of the adrenal cortex, stimulates it to functional activity, and shows extraadrenal adipokinetic activity; it is a polypeptide containing 39 amino acids, but exact structure varies from one species to another; sometimes prefixed by α to distinguish it from β-corticotropin. The first 13 amino acids at the N-terminal region are identical to α-melanotropin.
Farlex Partner Medical Dictionary © Farlex 2012


(ə-drē′nō-kôr′tĭ-kō-trŏp′ĭn, -trō′pĭn) also


(-trŏf′ĭn, trō′fĭn)
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


A gene on chromosome 2p23 that encodes proopiomelanocortin, the melanocortin family of hormones, which include alpha-, beta- and gamma-melanocyte stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). The melanocortins bind to the melanocortin receptors, a group of five G protein-coupled receptors (MC1R to MC5R) which are involved in a wide range of physiological functions, including pigmentation, energy homeostasis, inflammation, immunomodulation, steroidogenesis and temperature control.

Molecular pathology
Defects of POMC are associated with susceptibility to obesity and proopiomelanocortin deficiency.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Protein hormone of the anterior pituitary gland that stimulates the cortex of the suprarenal gland.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Adrenocorticotropin (corticotrophin)

A hormone that acts on cells of the adrenal cortex, causing them to produce male sex hormones and hormones that control water and mineral balance in the body.
Mentioned in: Pituitary Dwarfism
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
The ectopic adrenocorticotropin syndrome: Clinical features, diagnosis, management, and long-term followup.
The report provides comprehensive information on the Adrenocorticotropic Hormone Receptor (Adrenocorticotropin Receptor or Melanocortin Receptor 2 or MC2R or ACTHR), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
A novel vasoactive peptide, adrenomedullin, inhibits pituitary adrenocorticotropin release.
Influence of training on the response to exercise of adrenocorticotropin and growth hormone plasma concentrations in human swimmers.
[23] Lesions or manipulation of the paraventricular nuclei of the thalamus affect adrenocorticotropin responses in rats exposed to chronic mild stress.
Endocrine system leads to releasing of adrenocorticotropin, corticotropin-releasing hormone, cortisol, cytokine and prostaglandins in response to mother's physical and psychological stress by activating hypothalamus-pituitaryadrenal axis between mother and fetus.
In his 1999 study, Born and his fellow researchers found a hormone called adrenocorticotropin (ACTH) was found in higher levels in the blood when sleepers had an expectation to be woken up at a certain time.
Trunk blood was collected and allowed to clot, and the serum was stored at -20[degrees] C for IGF-I, IGF binding protein 3 (IGFBP3), adrenocorticotropin hormone (ACTH), corticosterone, and nitrite assays.
Abbreviations ACTH: Adrenocorticotropin hormone AVP: Arginine vasopressin CBG: Corticosterone binding globulin CRH: Corticotropin-releasing hormone EEG: Electroencephalography EH: Early handling HIDL: High initial damage load HPA: Hypothalamic-pituitary-adrenocortical LMS: Long-term maternal separation mRNA: Messenger ribonucleic acid MS: Maternal separation PVN: Paraventricular nucleus of the hypothalamus SHRP: Stress hyporesponsive period SMS: Short-term maternal separation TSST: Trier social stress test.
Pozza et al., "The ectopic adrenocorticotropin syndrome: clinical features, diagnosis, management, and long-term follow-up," Journal of Clinical Endocrinology and Metabolism, vol.
Increased plasma corticosterone and adrenocorticotropin were found in these animals [110, 111] which might be responsible for the "diabetic" alteration.

Full browser ?