adrenocorticotrophic hormone

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A 39-amino acid hormone produced by the anterior pituitary gland, which regulates adrenocortical activity, stimulating release of cortisol, mineralocorticoids, and adrenal androgens; pituitary ACTH is regulated by corticotropin-releasing hormone (CRH).
Daily pattern ACTH levels vary over the space of a 24-hour day, peaking at 6–8 am and evening 6–11 pm; ACTH suppression or stimulation testing may be required to confirm the diagnosis of changes in adrenal function.
ACTH increased in Addison’s disease, congenital adrenal hyperplasia, Cushing disease, pituitary-dependent Cushing syndrome, ectopic ACTH-producing tumours, Nelson syndrome.
ACTH decreased in Secondary adrenocortical insufficiency, adrenal carcinoma, adenoma. 
Ref range < 120 pg/mL
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

ad·re·no·cor·ti·co·tro·phic hor·mone

(ă-drēnō-kōŕti-kō-trōfik hōŕmōn)
Pituitary hormone that serves to stimulate the growth and nutrition of the suprarenal gland.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
* The two-bout exercise protocol seems a useful tool for prospectively diagnosing underperforming athletes, with an overshoot of adrenocorticotrophic hormone (ACTH) and prolactin (PRL) after the second exercise bout in NFO athletes and a suppression in OTS.
Adrenocorticotrophic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of the synthesis and actions of adrenocortical hormones.
Immunopanel Positive Inhibin Vimentin EMA Cytokeratin (+/-) Negative AFP PLAP hCG * ACTH indicates adrenocorticotrophic hormone; PLAP, placental alkaline phosphatase; hCG, human chorionic gonadotropin; AFP, [alpha]-fetoprotein; and EMA, epithelial membrane antigen.
CRH triggers the release of adrenocorticotrophic hormone (ACTH) by the pituitary gland, which, in turn, stimulates the adrenal glands to secrete cortisol.
Forty eight chickens were exposed to two of four variables; injection of synthetic ACTH (adrenocorticotrophic hormone), no injection of synthetic ACTH, a control diet, or a diet that contained an additional dose of ascorbic acid (AsA).
The study compared three methods of screening for adrenal insufficiency: the adrenocorticotrophic hormone (ACTH) stimulation test (the standard way to diagnose adrenal insufficiency in patients with clinical indications), measurement of morning serum cortisol levels, and measurement of adrenal antibody levels.

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