Although not identified until the present time, it is believed that some stimulating factor, probably a pituitary peptide present in the circulation, is responsible for adrenocortical hyperplasia
(JAVADI et al., 2005).
Comparable comments apply to localized unilateral nodular adrenocortical hyperplasia
. (123) Other pseudotumors with an endocrine underpinning include prostatic hyperplasias, (124,125) focal nodular hyperplasia of the liver (126) (Figure 14, A through D), ovarian stromal hyperthecosis, (127) the endometrial Arias-Stella reaction, (128) osteitis fibrosa cystica (brown tumor of hyperparathyroidism) (129,130) (Figure 15, A through D), and uterine cervical microglandular hyperplasia.
Other examples include a) the linkage between exposure to high PCB and methylsulfone (MeS[O.sub.2])-PCB and MeS[O.sub.2]-DDE concentration and a disease complex characterized by adrenocortical hyperplasia
in Baltic ringed seals, and b) chronic and reproductive toxicities observed for female mink fed a diet containing a mixture of environmentally relevant MeS[O.sub.2]-PCBs and MeS[O.sub.2]-DDE.
(3,5) These associated adrenal pathologic conditions include adrenocortical hyperplasia
, (3) adrenocortical adenomas, (3,5) adrenocortical carcinomas, (5) and endocrinologic dysfunctions, including Addison disease, (4) Conn syndrome, (5) 21-hydroxylase deficiency, (3) 17-hydroxylase deficiency, (6) and ectopic corticotropin production.
The persistent adrenocorticolytic DDT metabolite 3-methylsulfonyl-DDE (Me[SO.sub.2]-DDE) was originally identified in Baltic grey seals, a population suffering from adrenocortical hyperplasia
. In mice, Me[SO.sub.2]-DDE induces mitochondrial degeneration and cellular necrosis in the adrenal zona fasciculata.