adrenocortical carcinoma


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adrenocortical carcinoma

Oncology A rare–≤ 2 in 106/yr tumor of the adrenal cortex; average age 46; ♂:♀ ratio 1:2.5 Clinical ± 70% of Pts with AC have endocrine symptoms due to excess secretion of glucocorticoids and/or androgens, less commonly due to excess mineralocorticoids or estrogens Management Surgical resection, mitotane. See Mitotane.
Adrenocortical cancer
Stage I
CA < 5 cms; no spread to periadrenal tissues
Stage II
CA > 5 cms; no spread to periadrenal tissues
Stage III
CA spread to periadrenal tissues or lymph nodes
Stage IV
CA spread to regional tissues or organs, to lymph nodes around adrenal cortex, or metastasized
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References in periodicals archive ?
In these five years total 29 patients presented with adrenal tumour Of these, 13 had adrenocortical carcinoma. All the 13 patients were included in the study.
Mitotane levels predict the outcome of patients with adrenocortical carcinoma treated adjuvantly following radical resection.
Adrenocortical carcinomas can be associated with cysts that are benign on imaging; hence extensive sampling of resected tissues has been suggested to rule out malignancy.
Adrenocortical carcinoma: clinical outcomes and prognosis of 330 patients at a tertiary care center.
* The report reviews key players involved in the therapeutics development for Adrenocortical Carcinoma (Adrenal Cortex Cancer) and enlists all their major and minor projects
Total RNA was obtained from adrenocortical carcinomas using an RNeasy kit (Qiagen) according to the manufacturer's recommendations.
We have succeeded in developing a co-culture of H295R human adrenocortical carcinoma cells with characteristics of the fetal adrenal and BeWo human choriocarcinoma cells with characteristics of the villous trophoblast that exhibits the steroidogenic functionality of the human fetoplacental unit.
Histopathological examinations revealed adrenocortical hyperplasia in 23 (66%) patients, benign pheochromocytoma in 8 (22.8%) patients, and periadrenal paraganglioma, adrenocortical carcinoma, myeloid metaplasia, and myelol ipoma in 1 (2.8%) patient each.
Primary non-functional extra-adrenal adrenocortical carcinoma. Saudi Med J.
Lung metastectomy also improves outcomes in urinary transitional cell carcinoma, adrenocortical carcinoma, and testicular nonseminomatous germ cell cancer (5,6,7).
Red flags to watch for include multiple cancers within one patient, a family history of multiple early-onset cancers, rare tumors (e.g., adrenocortical carcinoma), or tumors that are particularly aggressive or treatment resistant.
Adrenocortical carcinoma with delayed cutaneous metastasis.