If we could decrease the formation of adrenochrome, we would have a treatment for schizophrenia.
And to decrease the oxidation of adrenalin to adrenochrome, we thought that large doses of ascorbic acid, the most effective water soluble antioxidant, would be helpful.
In the early 1950s it was shown that adrenochrome - something like a hybrid of adrenaline and mescaline - could produce symptoms identical with those of schizophrenia.
The American and British Freud-dominated psychiatric establishments angrily denied that adrenochrome and taraxein existed.
However, because oxidation of dobutamine to adrenochrome is rapid (complete within 5 min) under the Boehringer Mannheim reagent conditions, it is clear that reaction with 4-aminophenazone is not required for dobutamine to interfere in peroxidase-based tests.
Dobutamine oxidation under the Boehringer Mannheim reagent conditions was rapid, with complete oxidation to adrenochrome occurring in <5 min.
Oxidation process of adrenaline in freshly isolated rat cardiomyocytes: formation of adrenochrome
, quinoproteins, and GSH adduct," Chemical Research in Toxicology, vol.
Hoffer hypothesized that ascorbic acid's antioxidant activity also prevented the conversion of adrenaline to adrenochrome
Orthomolecular psychiatrist Abram Hoffer identified adrenochrome
as a possible factor in schizophrenia when he developed paranoia after ingesting the substance.
Osmond and I were invited to one of their meetings in 1952 held in the Canada Room (I thought that was very kind) of the Waldorf Astoria Hotel, where we for the first time reported our new hypothesis about adrenochrome
Osmond, I developed the first comprehensive hypothesis of schizophrenia with our adrenochrome
hypothesis; this led to megavitamin treatment and, later, to orthomolecular treatment in association with Linus Pauling.
To correct for the potential of over-reporting, the Student Drug Use Survey included one item about usage of a fictitious drug called adrenochromes
(also known as "wagon wheels").