adrenoceptor

ad·re·ner·gic re·cep·tors

reactive components of effector tissues, most of which are innervated by adrenergic postganglionic fibers of the sympathetic nervous system. Such receptors can be activated by norepinephrine and/or epinephrine and by various adrenergic drugs; receptor activation results in a change in effector tissue function, such as contraction of arteriolar muscles or relaxation of bronchial muscles; adrenergic receptors are divided into α-receptors and β-receptors, on the basis of their response to various adrenergic activating and blocking agents.

Adrenergic Receptor

Any of a family of G protein-coupled cell membrane receptors which receive neuronal impulses from postganglionic adrenergic fibres of the sympathetic nervous system, which are divided into:
(1) Alpha receptors, which evoke an excitatory response of smooth muscle cells to catecholamines. Alpha receptors are divided into alpha1 (Gq) and alpha2 (Gi) coupled receptors.
Selective agonist, alpha receptor Phenylephrine
Alpha receptor effects Vasoconstriction, reduced GI tract motility.
(2) Beta receptors, which dampen the response to catecholamines. Beta receptors are divided into beta1, beta2, beta3, which are linked to Gs, and adenylate cyclase, increasing cAMP, which in turn drives cAMP-dependent protein kinase that mediates intracellular events.
Selective agonist, beta receptor Isoprenaline
Beta receptor effects Increased cardiac output, increased renin secretion from juxtaglomerular cells, increased gastric ghrelin secretion, smooth muscle relaxation resulting in bronchodilation, reduced GI motility, relaxation of detrusor muscle of the bladder, lipolysis, glycogenolysis and gluconeogenesis, increased renin secretion, insulin secretion, vasodilation, anabolism and thermogenesis of skeletal muscle.

adrenoceptor

See BETA-ADRENOCEPTOR.

ad·re·ner·gic re·cep·tors

(ad'rĕ-nĕr'jik rĕ-sep'tŏrz)
Reactive components of effector tissues, most of which are innervated by adrenergic postganglionic fibers of the sympathetic nervous system. Such receptors can be activated by norepinephrine and/or epinephrine and by various adrenergic drugs.
Synonym(s): adrenoceptor.
References in periodicals archive ?
RHOFADE is a alpha1A adrenoceptor agonist approved for the topical treatment of persistent facial erythema associated with rosacea in adults, which is estimated to affect nearly 16 million people in the U.S.
A phase III, randomized, double-blind, parallel-group, placebo-controlled, multicentre study to assess the efficacy and safety of the [beta]3 adrenoceptor agonist, mirabegron, in patients with symptoms of overactive bladder.
- US-based specialty pharmaceutical company Velicept Therapeutics' next generation beta-3 adrenoceptor agonist solabegron met the primary endpoint in VEL-2002, a Phase 2b study in patients with overactive bladder, the company said.
A Phase III, randomized, double blind, parallel-group, placebo-controlled, multicentre study to assess the efficacy and safety of the b3 adrenoceptor agonist, mirabegron in patients with symptoms of overactive bladder.
(2006) [beta]2- and [beta]3- adrenoceptor polymorphisms relate to subsequent weight gain and blood pressure elevation in obese normotensive individuals.
ADRB2 is considered to be the key gene present on airway cells (hyperactive in asthma).6 b2 adrenoceptor agonists are major class in the treatment of asthma.
The searches followed the following strategy: (salmeterol OR formoterol OR LABAs OR long-acting beta 2 agonists) AND (adrenergic receptor OR ADRB2 OR adrenoceptor beta 2) AND (polymorphism OR SNP* OR variant OR mutation) AND asthma.
Wollenberger, "Effects of the serum gamma globulin fraction of patients with allergic asthma and dilated cardiomyopathy on chronotropic beta adrenoceptor function in cultured neonatal rat heart myocytes.," Biomedica Biochimica Acta, vol.
Chaplan, "Reversal of nerve ligation-induced allodynia by spinal alpha-2 adrenoceptor agonists," The Journal of Pharmacology and Experimental Therapeutics, vol.
Sequential binding of agonists to the [beta]2 adrenoceptor. J Biol Chem 2004; 279(1): 686-691.