adrenergic receptors


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Related to adrenergic receptors: cholinergic receptors

ad·re·ner·gic re·cep·tors

reactive components of effector tissues, most of which are innervated by adrenergic postganglionic fibers of the sympathetic nervous system. Such receptors can be activated by norepinephrine and/or epinephrine and by various adrenergic drugs; receptor activation results in a change in effector tissue function, such as contraction of arteriolar muscles or relaxation of bronchial muscles; adrenergic receptors are divided into α-receptors and β-receptors, on the basis of their response to various adrenergic activating and blocking agents.

ad·re·ner·gic re·cep·tors

(ad'rĕ-nĕr'jik rĕ-sep'tŏrz)
Reactive components of effector tissues, most of which are innervated by the sympathetic nervous system. Such receptors can be activated by norepinephrine, epinephrine, and adrenergic drugs; receptor activation results in a change in effector tissue function, such as contraction of arteriolar muscles or relaxation of bronchial muscles.
Synonym(s): adrenoreceptor.

adrenergic receptors 

Receptors which are stimulated by the catecholamines adrenaline (epinephrine) and noradrenaline (norepinephrine). These receptors belong to a family of G protein coupled receptors and are found in the central nervous system and many tissues innervated by the peripheral nervous system. There are two types of adrenergic receptors: (1) α-receptors, which are mainly excitatory to smooth muscles and gland cells but cause relaxation of intestinal smooth muscles; (2) β-receptors of which there are (at least) two types, β1 and β2. Generally, stimulation of β-receptors produces an inhibitory response, although in some cases the effect is excitatory (e.g. in the heart). Example: the dilator pupillae muscle contains mainly α-adrenergic receptors and stimulation (e.g. with adrenaline) produces mydriasis. On the other hand, there are drugs that block the effect of catecholamines on α- or β-adrenergic receptors and are called α- or β-blockers (or sympatholytic drugs or adrenergic receptor agonists). Example: the ciliary epithelium contains mainly β-receptors and a β-blocker such as timolol inhibits the secretion of aqueous humour, thus reducing intraocular pressure. Syn. adrenoceptor. See alpha-adrenergic agonists; alpha-adrenergic antagonists; beta-blocker; miotics; mydriatic; sympatholytic drugs; sympathomimetic drugs; autonomic nervous system.

ad·re·ner·gic re·cep·tors

(ad'rĕ-nĕr'jik rĕ-sep'tŏrz)
Reactive components of effector tissues, most of which are innervated by adrenergic postganglionic fibers of the sympathetic nervous system. Such receptors can be activated by norepinephrine and/or epinephrine and by various adrenergic drugs.
Synonym(s): adrenoceptor.
References in periodicals archive ?
The calculate results of binding free energy show that the main driving forces of [beta]-PEA binding ADR[beta]2 receptor are Van der Waals, electrostatic interactions and hydrophobic interactions, while tyramine binding with [beta]2 adrenergic receptor mainly by Van der Waals interaction.
Limbird, "Palmitoylation of the [[alpha].sub.2A]- adrenergic receptor. Analysis of the sequence requirements for and the dynamic properties of alpha 2A-adrenergic receptor palmitoylation," Journal of Biological Chemistry, vol.
These long I3 loops are found in [alpha]2 adrenergic receptors and some 5HT receptors.
The disappearance of the effects of tapentadol with the use of atipamezol suggests that the INR leads to the activation of the [alpha]2 adrenergic receptors of the postsynaptic cells in the dorsal horns and the primary terminal afferents (3).
A behavioral study of alpha-1b adrenergic receptor knockout mice: increased reaction to novelty and selectively reduced learning capacities.
Role of four polymorphisms of the [beta]-2 adrenergic receptor gen in patients with preterm delivery
Heart rate, cardiac inotropism and, hence, blood pressure (BP) increase with stimulation of [[beta].sub.1] adrenergic receptors and decrease with their blockade.
Heart beats in all mammals are stimulated by the binding of catecholamine to beta adrenergic receptors in these cardiac cells.
NaI exposure also influenced the mRNA expression of a wide range of rhodopsin-like G-protein-coupled receptors including adrenergic receptors. NaI increased [beta]-adrenergic receptor (Adrb2) gene expression in a dose-dependent manner, whereas PB and PTU increased 0q-adrenergic receptor (Adra1d) gene expression.
(4,13,14) Norepinephrine, which binds adrenergic receptors, has been reported to block neuronal firing in the medial vestibular nucleus while it stimulates neurons in the lateral vestibular nucleus.

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