adrenergic agonist

(redirected from adrenergic receptor agonist)

adrenergic agonist

A family of agents which have adrenaline-like effects, acting directly or indirectly on any of the five G-protein-coupled adrenergic receptors: apha1, alpha2, beta1, beta2, beta3.

Actions of adrenergic agonists
alpha1 receptors: Activate phospholipase C (via Gq), increasing protein kinase C activity.
alpha2: receptors Inhibit adenylate cyclase (via G1), decreasing protein kinase A activity.
beta receptors: Activate adenylate cyclase (via Gs), increasing protein kinase A activity.

adrenergic agonist

Any of a group of therapeutic agents, e.g. epinephrine, that mimic or stimulate the sympathetic nervous system.
See also: agonist

sympathomimetic drugs 

Drugs that produce an effect similar to that obtained by stimulation of the sympathetic nervous system. Some of these predominantly act on the adrenergic alpha-receptors (e.g. noradrenaline (norepinephrine)), while others act on the adrenergic beta-receptors (e.g. isoproterenol). Others have little direct effect on the adrenergic receptors but enhance the release of natural catecholamine from the sympathetic nerve terminals (e.g. amphetamine, phenylpropanolamine). Sympathomimetic drugs are used (1) in the treatment of open-angle glaucoma by decreasing aqueous humour secretion and increase the outflow through the trabecular meshwork thus reducing the intraocular pressure (e.g. adrenaline (epinephrine), apraclonidine, dipivefrine hydrochloride, brimonidine tartrate), (2) dilate the pupil without affecting accommodation (e.g. phenylephrine) and (3) constrict conjunctival blood vessels (e.g. naphazoline, tetrahydrozoline). Syn. adrenergic agonist; adrenergic stimulating agent. See alpha-adrenergic agonist; mydriatic.

ad·re·ner·gic ag·o·nist

(adrĕ-nĕrjik agŏ-nist)
An agent capable of combining with receptors to initiate actions of or like epinephrine.
See: agonist
See also: epinephrine
References in periodicals archive ?
Developed by scientists at NTU, the new type of skin patch contains hundreds of micro-needles, each of them thinner than a human hair, which are loaded with the drug beta-3 adrenergic receptor agonist or another drug called triiodothyronine, containing thyroid hormone T3.
INTUNIV is a selective alpha-2A adrenergic receptor agonist.
18 Similarly, nebulization of b2 adrenergic receptor agonist suggested for decreasing bronchospasm during flexible bronchoscopy in patients with asthma and bronchial hyperactivity.
Patients with contraindication to regional anaesthesia, history of significant coexisting diseases like ischaemic heart disease, hypertension, impaired renal functions, rheumatoid arthritis and severe liver disease, body weight more than 120 kg, height less than 140 cm, patient on adrenergic receptor agonist or antagonist therapy with known hypersensitivity to local anaesthetic, drugs, pregnant patients, chronic alcoholics and malnourished patients were excluded from the study.
The extended-release form of the drug, a selective alpha-2A adrenergic receptor agonist, previously had been approved as monotherapy for treating ADHD.
The extended-release form of the drug is a selective alpha-2A adrenergic receptor agonist and was first approved for the treatment of hypertension in 2002, and for ADHD in 2007.
Flucatisone is a corticosteroid and salmeterol is a selective long-acting beta-2 adrenergic receptor agonist.
The company added that the Phenylephrine Hydrochloride Ophthalmic Solution, USP, is an alpha-1 adrenergic receptor agonist indicated to dilate the pupil.
Intuniv, a once-daily formulation of guanfacine, is said to be the first selective alpha-2A adrenergic receptor agonist approved for the treatment of ADHD.
It is an alpha-1 adrenergic receptor agonist used for dilation of the pupil due to its vasoconstrictor and mydriatic action.
The alpha-2 adrenergic receptor agonist guanfacine (Tenex) also seems, on the basis of clinical experience and limited research, to have some value for hyperactivity, Dr.

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