adrenergic receptor


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Related to adrenergic receptor: cholinergic receptor

adrenergic receptor

Etymology: L, ad + ren, kidney; Gk, ergon, work; L, recipere, to receive
a site in a sympathetic effector cell that reacts to adrenergic stimulation. Two types of adrenergic receptors are recognized: alpha-adrenergic, which act in response to sympathomimetic stimuli, and beta-adrenergic, which block sympathomimetic activity. In general, stimulation of alpha receptors is excitatory of the function of the host organ or tissue, and stimulation of the beta receptors is inhibitory.

Adrenergic Receptor

Any of a family of G protein-coupled cell membrane receptors which receive neuronal impulses from postganglionic adrenergic fibres of the sympathetic nervous system, which are divided into:
(1) Alpha receptors, which evoke an excitatory response of smooth muscle cells to catecholamines. Alpha receptors are divided into alpha1 (Gq) and alpha2 (Gi) coupled receptors.
Selective agonist, alpha receptor Phenylephrine
Alpha receptor effects Vasoconstriction, reduced GI tract motility.
(2) Beta receptors, which dampen the response to catecholamines. Beta receptors are divided into beta1, beta2, beta3, which are linked to Gs, and adenylate cyclase, increasing cAMP, which in turn drives cAMP-dependent protein kinase that mediates intracellular events.
Selective agonist, beta receptor Isoprenaline
Beta receptor effects Increased cardiac output, increased renin secretion from juxtaglomerular cells, increased gastric ghrelin secretion, smooth muscle relaxation resulting in bronchodilation, reduced GI motility, relaxation of detrusor muscle of the bladder, lipolysis, glycogenolysis and gluconeogenesis, increased renin secretion, insulin secretion, vasodilation, anabolism and thermogenesis of skeletal muscle.

adrenergic receptor

Neurophysiology Any of a family of cell membrane receptors that receive neuronal impulses from postganglionic adrenergic fibers from the sympathetic nervous sytem, which are divided into α receptors, which results in an excitatory response of smooth muscle cells to catecholamines, and β receptors, which result in an inhibitory response to catecholamines; the GI tract is an exception, in that either α or β receptor stimulation results in relaxation

Adrenergic receptor

There are three families of adrenergic receptors, alpha1, alpha2 and beta, and each family contains three distinct subtypes. Each of the nine subtypes are coded by separate genes, and display specific drug specificities and regulatory properties.
References in periodicals archive ?
Beta 2 adrenergic receptor polymorphisms, at codons 16 and 27, and bronchodilator responses in adult Venezuelan asthmatic patients.
The presence of seven transmembrane segments in rhodopsin (37) and O adrenergic receptors (38) was suggested by their amino acid sequences, which were determined in 1980 by protein analysis and in 1986 by cDNA screening, respectively.
On the other hand, it is capable of inhibiting serotonin and norepinephrine reuptake and can bind to [alpha]2 adrenergic receptors as well as potentiating the neuronal release of serotonin (8, 16, 17).
A functional polymorphism in the alpha-2B adrenergic receptor gene, a positional candidate gene on chromosome 2, is associated with hypertension in Swedes.
2]AR) adrenergic receptor are associated with spontaneous preterm delivery.
Histologically, beta-2 adrenergic receptors are located primarily within bronchiole smooth muscle; beta-1 adrenergic receptors are located within the cardiovascular system.
Dow explains this is because they were developed before the human beta-3 adrenergic receptor had been identified.
INTUNIV is a selective alpha-2A adrenergic receptor agonist.
Furthermore, a non-selective serotonin receptor antagonist, metergoline (4), and a [alpha]-2a adrenergic receptor antagonist, BRL44408 (5), were used to evaluate the roles of the serotoninergic and adrenergic systems, respectively

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