adrenergic receptor


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Related to adrenergic receptor: cholinergic receptor

Adrenergic Receptor

Any of a family of G protein-coupled cell membrane receptors which receive neuronal impulses from postganglionic adrenergic fibres of the sympathetic nervous system, which are divided into:
(1) Alpha receptors, which evoke an excitatory response of smooth muscle cells to catecholamines. Alpha receptors are divided into alpha1 (Gq) and alpha2 (Gi) coupled receptors.
Selective agonist, alpha receptor Phenylephrine
Alpha receptor effects Vasoconstriction, reduced GI tract motility.
(2) Beta receptors, which dampen the response to catecholamines. Beta receptors are divided into beta1, beta2, beta3, which are linked to Gs, and adenylate cyclase, increasing cAMP, which in turn drives cAMP-dependent protein kinase that mediates intracellular events.
Selective agonist, beta receptor Isoprenaline
Beta receptor effects Increased cardiac output, increased renin secretion from juxtaglomerular cells, increased gastric ghrelin secretion, smooth muscle relaxation resulting in bronchodilation, reduced GI motility, relaxation of detrusor muscle of the bladder, lipolysis, glycogenolysis and gluconeogenesis, increased renin secretion, insulin secretion, vasodilation, anabolism and thermogenesis of skeletal muscle.

adrenergic receptor

Neurophysiology Any of a family of cell membrane receptors that receive neuronal impulses from postganglionic adrenergic fibers from the sympathetic nervous sytem, which are divided into α receptors, which results in an excitatory response of smooth muscle cells to catecholamines, and β receptors, which result in an inhibitory response to catecholamines; the GI tract is an exception, in that either α or β receptor stimulation results in relaxation

Adrenergic receptor

There are three families of adrenergic receptors, alpha1, alpha2 and beta, and each family contains three distinct subtypes. Each of the nine subtypes are coded by separate genes, and display specific drug specificities and regulatory properties.
References in periodicals archive ?
Adrenergic receptors (ADR) can be activated by catecholamines adrenaline and noradrenaline [15].
Study the Possible Role of b2 Adrenergic Receptor Gene in the Pathogenesis of Bronchial Hyperresponsiveness in Asthmatic Patients and its Relation to Disease Severity and Treatment Response.
The palmitoylation of the adrenergic receptors belonging to the [alpha]2AR group was extensively investigated as well.
The presence of seven transmembrane segments in rhodopsin (37) and O adrenergic receptors (38) was suggested by their amino acid sequences, which were determined in 1980 by protein analysis and in 1986 by cDNA screening, respectively.
McDonald et al., "Polycyclic aromatic hydrocarbons impair function of [beta]2- adrenergic receptors in airway epithelial and smooth muscle cells," The American Journal of Respiratory Cell and Molecular Biology, vol.
Likewise, the inhibition of norepinephrine reuptake (INR) in the axonic endings of the inhibitory noradrenergic descending pathways, increases the extracellular concentration of norepinephrine (NE) in the spinal cord, which can also produce anti-nociception by the activation of the [alpha]2 adrenergic receptors which can be of particular interest in chronic neuropathic pain.
To conclude, the present study established the genotype and allele frequencies of [[beta].sub.1] adrenergic receptor gene polymorphisms in a South Indian Tamilian population.
Substitution of a mutant alpha-2A adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic- sparing responses in vivo.
A behavioral study of alpha-1b adrenergic receptor knockout mice: increased reaction to novelty and selectively reduced learning capacities.
Eighteen drugs are in Phase III development in the US including two GABA receptor agonists pregabalin (Pfizer) and gabapentin GR (Depomed); a sodium channel antagonist mexiletine (Boehringer Ingelheim); three glutamate / NMDA antagonists ketamine intranasal (Javelin), a dextromethorphan/quinidine combination (Avanir), and NP-1 (EpiCept/Epitome); two serotonin/norepinephrine reuptake inhibitors desvenlafaxine (Wyeth), and paroxetine (GSK/Novo Nordisk); an alpha-2 adrenergic receptor antagonist/norepinehrine reuptake inhibitor reboxetine (Pfizer); an opioid receptor agonist/norepinephrine reuptake inhibitor tapentadol (Ortho-McNeil); a dopamine receptor agonist sodium oxybate (Jazz), and a neuromuscular blocking agent botulinum toxin A (Allergan).
MAINTENANCE OF BETA ADRENERGIC RECEPTOR SIGNALING IN HUMAN MICROVASCULAR RETINAL ENDOTHELIAL CELLS.

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