Ipratropium is an anticholinergic bronchodilator, and albuterol is a selective beta 2 adrenergic bronchodilator
. Combivent inhalers are indicated for people with COPD, on a regular bronchodilator who continue to have evidence of bronchospasm and who require a second bronchodilator.
Cardiotoxicity of adrenergic bronchodilator
and vasodilating antihypertensive drugs.
* Corticosteroid plus short-acting beta-2 adrenergic bronchodilator
* Anticholinergic bronchodilator plus short-acting beta-2 adrenergic bronchodilator
Often, using an inhaled adrenergic bronchodilator
before exercise can prevent exercise-induced symptoms and allow people to be fully active.
The general indication for use of an adrenergic bronchodilator
is relaxation of airway smooth muscle in the presence of reversible airflow obstruction associated with acute and chronic asthma (including exercise-induced asthma), bronchitis, emphysema, bronchiectasis, and other obstructive airway diseases.
The most common clinically observed side effects of adrenergic bronchodilators are tremor, tachycardia, tolerance to bronchodilator effect, loss of bronchoprotection, nervousness, worsening ventilation to perfusion ratio, hypokalemia, and sensitivity to additives and propellants.
Commonly reported side effects of the adrenergic bronchodilators include headache, nervousness, irritability, anxiety, and insomnia, which are caused by central nervous system stimulation.
The action of salmeterol in providing sustained protection from bronchoconstriction differs to a degree from that of the previously described adrenergic bronchodilators
. The difference in salmeterol's pharmacodynamics is reflected in its pharmacokinetics with a slower onset and time to peak effect and a longer duration of action compared with previous adrenergic agents.
I will also discuss the benefits anticholingergic bronchodilators have when used in combination with adrenergic bronchodilators
In the last two issues I had discussed the use of short and long acting adrenergic bronchodilators
. I have not discussed in any detail however, a little something known as side effects.