The prescribing information says that mometasone furoate exerts less effect on the hypothalamic-pituitary-adrenal axis than other inhaled corticosteroids, and that adrenal suppression
is unlikely to occur when used at recommended dosages.
Patients taking steroids have a significant risk of Adrenal suppression
caused due to suppression of hypothalamic pituitary axis leading to adrenal insufficiency.
Seven studies with a primary end-point of adrenal suppression
performed on 1303 patients were analyzed separately.
levels of serum cortisol; taken at 0800 hrs following 3 weeks of treatment, less than 3 ug/dl (83nmol/l) was taken as cases of adrenal suppression
Presumed mechanisms of action are either maternal hyperglycemia or fetal adrenal suppression
or both, with potential for fetal adrenal suppression
resulting from betamethasone exposure to affect long-term metabolic outcomes.
Clinical impact of corticosteroid-induced adrenal suppression
during treatment for acute lymphoblastic leukemia in children: a prospective observational study using the low-dose adrenocorticotropin test.
1) However Propofol remains the most commonly used agent in hypertensives inspite of the possibility of precipitous hypotension due to the fear of adrenal suppression
caused by etomidate.
may happen by ophthalmologists' extensive use of topical steroids (13).
One of the major concerns in topical therapies for psoriasis, especially in patients with widespread disease, is the potential for not only topical adverse effects (AEs), such as irritation and atrophy, but also systemic AEs, such as adrenal suppression
with topical steroids and calcium homeostasis with the use of Vitamin D3 compounds.
The patient had severe adrenal suppression
, which developed after daily use of 4g clobetasol propionate (28g/week) ointment, which was high for an 11-month-old infant.
Other side effect of inhalers, such as glaucoma, cataracts, and adrenal suppression
, are also more common.
Women who use inhalers to treat their asthma also have a higher risk of adverse events associated with inhaler use, including osteoporosis, glaucoma, cataracts, and adrenal suppression