The most common form is classic CAH due to 21-hydroxylase deficiency (MIM 202010), a condition characterised by low synthesis of glucocorticoids and, in many cases, mineralocorticoids (i.e., in the salt loosing variant) and adrenal hyperandrogenism
. More rare forms are caused by deficiency of 11[beta]-hydroxylase, 17[alpha]-hydroxylase, 3[beta]-hydroxysteroid dehydrogenase, or P450 oxidoreductase .
Sacerdote, "Novel endocrine disrupter effects of classic and atypical antipsychotic agents and divalproex: induction of adrenal hyperandrogenism
, reversible with metformin or rosiglitazone," Endocrine Practice, vol.