Prolactin and oxytocin release during suckling seems to add to this latter effect by acting to decrease breastfeeding women's HPA-axis responsiveness, and likely their episodic release of
adrenal androgens as well.
Adrenal androgen dehydroepiandrosterone sulfate inhibits vascular remodeling following arterial injury.
Monitoring of Glucocorticoid Replacement and
Adrenal Androgen Suppression
DHEA is used as a marker of
adrenal androgen production; abnormally low concentrations of DHEA may occur in patients with adrenal insufficiency, older adults, and peri- and postmenopausal women.
In addition to increased androgen synthesis in the ovary, there is a significant increase in
adrenal androgen levels seen in many women with PCOS.
Low-dose glucocorticoids work by suppressing
adrenal androgen production.
6) Additionally, methyltestosterone prevents suppression of
adrenal androgen synthesis by estrogen treatment alone, thus allowing for enhanced peripheral androgen bioconversion to estrogen.
In its research, Hollis-Eden screened compounds from its library that inhibited
adrenal androgen stimulated proliferation of human LnCaP prostate cancer cells in vitro.
This in turn stimulates estrogen production in the adrenal cortex or
adrenal androgen conversion to estrogen in peripheral tissue.
This influence of
adrenal androgen, however, was observed for [Delta]5-androstenediol using concentrations reported in the literature (data not shown).
13) Little data exist about the effects of use of exogenous
adrenal androgen alone on BMD.
Prevalence of 3[beta]-hydroxysteroid dehydrogenase-deficient nonclassic adrenal hyperplasia in hyperandrogenic women with
adrenal androgen excess.
