adrenal androgen


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a·dre·nal an·dro·gen

any androgenic hormone of adrenocortical origin; for example, dehydroepiandrosterone (and its sulfate), androstenedione, 11β-hydroxyandrostenedione.

adrenal androgen

Any of the male sex hormones produced and released by the adrenal glands instead of by the testes. In women, they may cause subfertility, infertility, or other conditions.
See also: androgen
References in periodicals archive ?
Abiraretone is a potent inhibitor of CYP17A1, required for the synthesis of gonadal and adrenal androgens. Combined use of abiraterone with glucocorticoids can effectively lower androstenedione and testosterone metabolites in adult women with 21OHD without any potential side effects including hypertension and hypokalemia.
Thijssen, "Adrenal androgen secretion and metabolism in postmenopausal women," in Adrenal Androgens, A.
Monitoring of Glucocorticoid Replacement and Adrenal Androgen Suppression
Aging accounts for much of the reduction in both ovarian and adrenal androgen production, but natural menopause does not result in an abrupt decline in testosterone production.
At baseline, women with FSD had significantly decreased levels of testosterone and adrenal androgen precursors (dehydroepiandrosterone-sulfate, or DHEA-S) but not ovarian androgen precursors (androstenedione), compared with women with normal sexual function.
Combined oral contraceptives reduce levels of androgen, especially testosterone, by inhibiting ovarian and adrenal androgen synthesis and by increasing levels of sex hormone-binding globulin (SHBG).
In males, the testes secrete approximately 95% of testosterone and the rest is made from adrenal androgen precursors by the peripheral conversion (in liver, skin, and adipose tissue) of androstenedione.
Low-dose glucocorticoids work by suppressing adrenal androgen production.
(6) Additionally, methyltestosterone prevents suppression of adrenal androgen synthesis by estrogen treatment alone, thus allowing for enhanced peripheral androgen bioconversion to estrogen.
In addition to increased androgen synthesis in the ovary, there is a significant increase in adrenal androgen levels seen in many women with PCOS.
(13) Little data exist about the effects of use of exogenous adrenal androgen alone on BMD.