adoptive transfer


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Related to adoptive transfer: Flow cytometry, transgenic

Adoptive Immunotherapy

A form of passive immunisation in which sensitised cells or serum are transferred to an immunologically naive or lymphocyte-depleted recipient—e.g., for managing cancer, as in the use of IL-2/LAK cells.
About 10% of patients with terminal renal cell carcinoma and melanoma achieve partial or complete remission with LAK/IL-2; some response to LAK cells may occur in colorectal carcinoma and Hodgkin lymphoma; the effects may be dose-dependent, non-MHC-restricted, and require simultaneous high-dose IL-2.

adoptive transfer

the transfer of cells, commonly lymphocytes from an immunized individual, to a non-immune recipient.
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T cells in an intrinsic or extrinsic fashion, we performed reciprocal adoptive transfer experiments.
In contrast, an increase in the proportion of Tregs was likely due to a combination of intrinsic and extrinsic influences because the skewed frequency of Tregs was lost in both adoptive transfer scenarios.
In the adoptive transfer experiments we saw that an equal fraction of treated and non-treated cells initiated proliferation in the recipients.
In some experiments adoptive transfers were made to C57BL/6 mice that had been irradiated (300 Rad) 24 hours prior to cell transfer.
In the adoptive transfer technique, investigators used a small fragment of a patient's melanoma to grow the patient's own T cells in vitro (Science, 19 September 2002 [10.
Adoptive transfer might be useful in other cancers and in infectious diseases such as AIDS for which functionally active lymphocytes can be selected in vitro.
Adoptive transfer of granulocyte-macrophage colony-stimulating factor (GM-CSF) +IL-6-inducing MDSCs from bone marrow cells could prevent allograft rejection and allow long-term survival of pancreatic islet allografts.
Interestingly, adoptive transfer of ES-MDSCs can effectively prevent lethal GVHD in mice and lead to long-term survival among treated mice [50].
Adoptive transfer of M2 macrophages into fungal sensitized and challenged mice resulted in exacerbated inflammation and fibrosis in the lung, whereas adoptive transfer of naove macrophages reduced inflammation and fibrosis.
Treatment of M2 macrophages with PTX-2/SAP prior to adoptive transfer altered M2 macrophage function thereby restoring the ability of these cells to reduce inflammation and fibrosis and was associated with a significant increase in IL-10 production in the lung.
In the study, recipient athymic mice were irradiated sublethally and injected with human hepatoma cells followed by the adoptive transfer of splenocytes from donor mice.