adoptive immunotherapy


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a·dop·tive im·mu·no·ther·a·py

passive transfer of immunity from an immune donor through inoculation of sensitized lymphocytes, or antibodies in serum or gamma globulin.

adoptive immunotherapy

n.
A form of immunotherapy used in the treatment of cancer and certain viral infections in which lymphocytes taken from a patient are stimulated, activated, and infused back into the patient.

Adoptive Immunotherapy

A form of passive immunisation in which sensitised cells or serum are transferred to an immunologically naive or lymphocyte-depleted recipient—e.g., for managing cancer, as in the use of IL-2/LAK cells.
About 10% of patients with terminal renal cell carcinoma and melanoma achieve partial or complete remission with LAK/IL-2; some response to LAK cells may occur in colorectal carcinoma and Hodgkin lymphoma; the effects may be dose-dependent, non-MHC-restricted, and require simultaneous high-dose IL-2.

a·dop·tive im·mu·no·ther·a·py

(ă-dop'tiv im'yū-nō-thār'ă-pē)
Passive transfer of immunity from an immune donor through inoculation of sensitized lymphocytes, transfer factor, immune RNA, or antibodies in serum or gamma globulin.
References in periodicals archive ?
Adoptive immunotherapy is a process in which researchers remove a small amount of blood from the patient and isolate the very small number of CTLs specific for the disease present in the patient.
In this capacity, he directed the development and documentation of a closed-system, large-scale process for preparing, culturing, harvesting and shipping of patient T-cells for use in adoptive immunotherapy protocols.
Speaking on behalf of her team, the recipient of the Grant, Dr Celia Gomes said: "The main goal of this project is to evaluate the potential of NK-based adoptive immunotherapy in the eradication of cancer stem cells in bladder cancer and its impact in tumor progression, using a humanised animal model closely resembling the clinical situation.
Cellectis founded the field of gene editing 14 years ago and is now primarily focused on adoptive immunotherapy using TALEN -engineered T cells combined with (CARs).
At the 27th Annual Meeting, prominent investigators summarized central themes and recent research in tumor immunology and cancer immunotherapy including innate immunity, dendritic cells, T cell differentiation, antibody therapy, and the tumor microenvironment as well as recent advances in the clinical application of cancer vaccines, coinhibition and costimulation of immune cells for immunotherapy, adoptive immunotherapy, and immune monitoring in clinical trials of cancer immunotherapies.
The report also includes a survey on adoptive immunotherapy for cancer, which was conducted by a team of expert analysts in conjunction with this report, and is discussed in Chapter 5.
Martin Pule as well as being a senior Lecturer in UCL, holds an honorary consultant post as a clinical hematologist in the UCL Hospital (UCLH) and runs a laboratory research program in chimeric antigen receptor design and adoptive immunotherapy.
CHAPTER 1: Introduction CHAPTER 2: Checkpoint Inhibitors CHAPTER 3: Therapeutic anticancer vaccines CHAPTER 4: Adoptive Immunotherapy for Cancer CHAPTER 5: Summary and Conclusions For more information visit http://www.
At The James, research in adoptive immunotherapy is under way for certain patients with advanced colon cancer.
We view T-cell adoptive immunotherapy as particularly appealing for patients whose tumor burdens might be too large or too aggressive to warrant administration with cancer vaccines.
While little research has been carried out in the role adoptive immunotherapy can play in the fight against HIV and Aids, there has been a pre-clinical study into what happens when monkeys with chronic SIV infection - the equivalent of HIV - are given re-infusions of their own non-diseased white blood cells.