adnexal carcinoma

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ad·nex·al car·ci·no·ma

a carcinoma arising from sweat or sebaceous glands.
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Microcystic Adnexal Carcinoma Differential Diagnosis: The classic differential diagnosis for MAC is desmoplastic trichoepithelioma, syringoma, and infiltrative/morpheaform basal cell carcinoma (Figure 10, A through C).
Histopathological Mean age diagnoses n (%) (years) M/F Primary malignancy BCC 124 (61.4) 63.3 82/42 SCC 33 (16.3) 58.1 22/11 MF 14 (6.8) 30.7 11/3 DFSP 12 (5.8) 32.3 8/4 MM 7 (3.7) 65.1 6/1 Bowen's disease 3 (1.5) 62.7 2/1 Adnexal carcinoma 3 (1.5) 68.3 3/0 PDS 1 (0.5) 85.0 1/0 Kaposi's sarcoma 1 (0.5) 80.0 1/0 MCC 1 (0.5) 75.0 1/0 Metastatic Metastatic 3 (1.5) 48.0 2/1 adenocarcinoma Total 202 (100) 139/63 BCC--Basal cell carcinoma, SCC--squamous cell carcinoma, MF--mycosis fungoides, DFSP--dermatofibrosarcoma protuberans, MM--malignant melanoma Table 2--Distribution of the cases according to the locations.
With microcystic adnexal carcinoma it is difficult to differentiate from infiltrating basal cell carcinoma and desmoplastic trichoepithelioma.
BerEP4 has been found to be able to differentiate BCC from other cutaneous pathologies such as squamous cell carcinoma, basosquamous cell carcinoma, collision tumors, sebaceoma, microcystic adnexal carcinoma, ameloblastoma, epidermoid cysts, actinic keratosis, seborrheic keratosis, poroma, lichen planus like keratosis, nevi, hemangioma, inverted follicular keratosis, squamous intraepithelial neoplasia, and sebaceous adenoma/hyperplasia.
Wladis et al., "A unique mucin producing adnexal carcinoma of the eyelid," Journal of Cutaneous Pathology, vol.
Any large basaloid tumor presenting in the dermis, including poorly differentiated adnexal carcinoma or metastatic carcinoma, has the potential to be mistaken for BCC if attention is not given to the clinical presentation, high-grade cytologic atypia, and absence of hallmark features of BCC.
The more common subtypes include microcystic adnexal carcinoma, eccrine porocarcinoma, and hidradenocarcinoma.
There are usually three patterns of EMPD: a) an in situ epithelial form without associated carcinoma, b) an epithelial form with associated adnexal carcinoma and c) associated with visceral malignancy of either genitourinary tract or gastrointestinal tract.6 EMPD cells themselves have the potential to invade the dermis and metastasize.
Histopathologically, the deep and plaque types can be mistaken for microcystic adnexal carcinoma. (68,69) We did not identify any unusual variants of syringoma, such as giant, plaque-like, or clear cell variants.
Based on the results of the database search, 27 cases were retrieved from the University of Pittsburgh Medical Center archives for the study: 12 cases of ductal CMBC (44%), which included 11 cases with morphologies not otherwise specified and 1 case of basal phenotype; 11 cases of SGC (41%), which included 5 cases of EC, 3 cases of porocarcinoma (PC), and 3 cases of microcystic adnexal carcinoma (MAC); and 4 additional, randomly selected cases (15%), which included 2 primary cutaneous adnexal benign neoplasms (a poroma and an apocrine adenoma) and 2 cases of PBC.
(5) The clearly malignant features of this neoplasm required diagnosis as syringocystadenocarcinoma papilliferum, a rare, malignant, primary cutaneous adnexal carcinoma. The neoplasm extended to multiple resection margins with evidence of perineural invasion.
Syringomatous carcinoma (microcystic adnexal carcinoma; cases 42-44) represents a spectrum of infiltrative epithelial tumors that resemble syringomas.