admixture mapping

admixture mapping

Gene mapping of populations of mixed ancestry—e.g., African Americans, Latino/Hispanics—to identify gene loci responsible for differences in disease frequencies. Admixture mapping attempts to correlate the degree of ancestry near a gene locus to a disease or trait of interest, and assumes that differences in disease rates are linked to differences in the frequencies of disease-causing genetic variants between populations. In an admixed population, these causal variants occur more frequently on chromosomal segments inherited from one or the other ancestral population.
References in periodicals archive ?
Future large scale admixture mapping with the MA will be especially useful to identify novel SLE susceptibility genes.
The researchers used their newly developed method of "admixture mapping" to screen through the genome in blacks (who have African and European ancestry), searching for the segments where individuals with disease have more of one ancestry than the average.
Hafler's "admixture mapping" studies of African-Americans with MS.
Skin pigmentation, biogeographical ancestry and admixture mapping. Hum.