Lactate production by Sertoli cells is important physiologically because developing spermatogenic cells in the adluminal
compartment of the seminiferous epithelium have no other source of this compound.
6,7) This lesion, named focal orchitis by Honore, (16) has been explained as an autoimmune process produced by an alteration of the blood-testis barrier that permits the passage of antigens from the adluminal
tubular compartment to the testicular interstitium.
These authors described both adluminal
and basally located cells.
From 10 weeks of age, cPdcl2 mRNA expression was detected within the adluminal
Staining for cytokeratin 7 tends to mark an adluminal
cell population and basal cell cytokeratin (34[beta]E12) stains the more peripheral cells.
Transferrin gene codes the formation of the iron transport glycoprotein, transferrin which is important in the delivery of iron to germinal cells within the adluminal
compartment of the seminiferous tubules (55-56).