"Glucocorticoids in nano-liposomes administered intravenously and subcutaneously to adjuvant arthritis
rats are superior to the free drugs in suppressing arthritis and inflammatory cytokines." Journal of controlled release, 160(2): pp.299-305 (2012).
This study has examined the potential that CIE has to play an important role in treating and preventing adjuvant arthritis
, and the results are promising regarding its therapeutic role as a therapeutic agent against inflammatory conditions.
(2) The rats in the six groups AA, DMA, QPO, WGYKl, WGYKm, and WGYKh were injected with 0.1 mL of Freund's complete adjuvant in the skin of right rear toe, to establish the model of adjuvant arthritis
Valachova et al., "Carnosine inhibits degradation of hyaluronan induced by free radical processes in vitro and improves the redox imbalance in adjuvant arthritis
in vivo," Neuro Endocrinology Letters, vol.
Role of Nigella sativa oil, thymoquinone with and without pyremethamine in Freund's adjuvant arthritis
Rat adjuvant arthritis
is a widely used classic model, which shares many similar characteristics to RA in human, including histology and immunology (Jawed et al.
injection of liposomally encapsulated dexamethasone phosphate was evaluated in comparison to that of free drug in rats with established adjuvant arthritis
. Liposomal-dexamethasone phosphate suppressed haematological signs of arthritis including erythrocyte sedimentation rate, white blood cell count, circulating antimycobacterial IgG, and production of IL-1 and IL-6 by macrophages in a dose-dependent manner for dosage between 0.01 and 1.0 mg/kg.
In adjuvant arthritis
, the cellular immune response to mycobacterial antigens has been detected and is probably involved in the development of arthritis .
GS is widely used to treat or prevent osteoarthritis in humans.21 Several shortand long term clinical trials in osteoarthritis have shown the significant symptom-modifying effect of glucosamine.22 Some data showed that glucosamine can prevent experimentally induced cartilage degradation.23 Hua et al reported, microscopically and biochemically the effect of glucosamine, suppressed not only the increase in the swelling of joints and the arthritis score but also the histopathological changes of joints in adjuvant arthritis
(synovial hyperplasia, pannus formation with cartilage erosion, and leukocyte infiltration.7 But, on the contrary as clinically, our study had no effect in the GS group patients.
Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant arthritis
. Arthritis Rheum.
Modulation of inflammatory markers by the ethanolic extract of Leucas aspera in adjuvant arthritis
. Journal of Ethnopharmacology, 134: 1024-1027.
Freunds adjuvant arthritis
(AA) of rats is a widely used experimental model that mimics human chronic arthritis immune disorders (Ruth 2001, Colpaert 1982, Hirschelmann 1986).