adipsin

Adipsin

A serine protease secreted by adipocytes into the circulation which is deficient in some animal models of obesity. It is identical to complement factor D.

adipsin

An enzyme secreted by fat cells, and also present in the Schwann cells of nerve fibres, that is thought to regulate fat metabolism. It acts on free lipoproteins and is concerned with fat oxidation. Its levels are markedly reduced in genetically obese mice. The full function of adipsin remains unclear.
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This leads to transcription of insulin-response genes (such as adiponectin and adipsin) thereby mediating antidiabetic effects.
aggrecan were expressed (iii) Adipogenesis: adipsin, PPAR?, and lipoprotein lipase (2) ALP activity was signi?cantly increased in BMP2-induced UC-MSCs (i) Western blot revealed activation of the BMP2 signaling pathway in both cell types via SMADs, p38, and extracellular regulated kinase activation
Gene M84526 codes another serine protease adipsin which is secreted by adipocytes into the bloodstream and functions as part of the alternative complement pathway of the innate immune system [29].
Adipsin, monocyte chemoattractant protein-1 (MCP-1), and macrophage inflammatory protein-1[beta] (MIP-1[beta]) increased concentrations have also been reported in the CSF of ALS patients.
Ruiz-Linares et al., "Serum adipsin levels throughout normal pregnancy and preeclampsia," Scientific Reports, vol.
This study determined the levels of complement 3 (C3), acylation-stimulating protein (ASP), and adipsin, which take part in the alternate complement pathway, and are synthesized in and secreted by adipose tissue.
Enzyme-linked immunosorbent assay (ELISA) was performed using commercial reagents for YKL-40, adipsin, MMP-9, CRP (R&D Systems Europe Ltd., Abingdon, U.K.), and IL-6 (Sanquin, Amsterdam, The Netherlands).
Moreover, in human SGBS adipocytes, quercetin can significantly reduce levels of adipokines ANGPTL4, adipsin, and PAI-1 as well as of glycolysis-associated enzymes ENO2, PFKP, and PFKFB4, all of which are associated with obesity and adipose tissue dysfunction [41].
Among these many adipokines includes; adiponectin, leptin, resistin, visfatin, adipsin, apelin, cheperin and retinol binding protein-4 (RBP-4) [2,4].
Adipsin and an endogenous pathway of complement from adipose cells.J Biol Chem1992;267:12736-41.
These secretory proteins, which have been collectively named adipocytokines, include leptin, tumor necrosis factor (TNF)-[alfa], plasminogen-activator inhibitor type 1 (PAI-1), adipsin, resistin and adiponectin [5].