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a disorder characterized primarily by obesity and hypogonadotrophic hypogonadism in adolescent boys; dwarfism is rare, and when present is thought to reflect hypothyroidism. Vision loss, behavioral abnormalities, and diabetes insipidus may occur. Fröhlich syndrome is a common synonym for this disorder. Although the original case involved a pituitary tumor, most cases are thought to result from hypothalamic dysfunction in areas regulating appetite and gonadal development. The most common causes are pituitary and hypothalamic neoplasms.
adiposogenital dystrophy, adiposogenital syndrome
a disease characterized by abnormal distribution of fat (obesity) accompanied by underdevelopment of the genitalia. The condition is caused by damage to certain parts of the hypothalamus, with a decrease in the secretion of gonadotropic hormones from the anterior lobe of the pituitary gland. Treatment depends on the primary cause of the condition, usually a tumor or infection involving the hypothalamus. Called also Fröhlich's syndrome.