adiponectin


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Related to adiponectin: ghrelin, Resistin

ad·i·po·nec·tin

(ad'i-pō-nek'tin),
Protein hormone produced and secreted by adipocytes into the systemic blood circulation; causes sensitivity of peripheral tissues to insulin.
[adipo- + L. necto, to fasten, + -in]

adiponectin

(ăd′ə-pə-nĕk′tĭn)
n.
A polypeptide hormone that is secreted by fat cells and regulates glucose and lipid metabolism, especially by increasing insulin sensitivity and muscle uptake of glucose and by decreasing glucose production in the liver.

Adiponectin

A circulating protein encoded by ADIPOQ on chromosome 3q27, which is secreted exclusively by mature adipocytes. It is a key adipokine in the control of fat metabolism and insulin sensitivity, and has direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. It stimulates AMPK phosphorylation and activation in the liver and skeletal muscle, enhancing glucose utilisation and fatty acid hydrolysis. It antagonises TNF-alpha by down-regulating its expression in the liver, macrophages and elsewhere, and by counteracting its direct effects. It inhibits endothelial NF-kappa-B signalling by a cAMP-dependent pathway. It may play a role in cell growth, angiogenesis and tissue remodelling by binding and sequestering various growth factors with distinct binding affinities, depending on complex size—low, medium, or high molecular weight.

ad·i·po·nec·tin

(ad'i-pō-nek'tin)
Protective adipokine that reduces lipid accumulation and endothelial adhesion resulting from vascular injury; increases skeletal muscle oxidation of free fatty acids; reduces hepatic glucose output; increases peripheral insulin sensitivity.
[adipo- + L. necto, to fasten, + -in]

adiponectin

A cytokine derived from adipose tissue that has antidiabetic and antiatherosclerotic properties.
References in periodicals archive ?
Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway.
Insulin and adiponectin levels were estimated using commercially available enzyme-linked immunosorbent assay kits.
These findings suggest that NMS might have little or no effect on adiponectin secretion from adipocytes.
Serum adiponectin levels, [13,14] serum leptin levels [15] and serum insulin levels [16] were determined by enzyme linked immunosorbent assay (ELISA).
Although, a limited number of studies have shown illicit drugs such as heroin to cause a dysregulated production of host circulating adiponectin levels [23,24].
ALPCO's Total Adiponectin and HMW & Total Adiponectin ELISAs are For Research Use Only in the United States.
There were no correlations between corresponding breast cyst fluid and plasma levels of leptin, adiponectin, visfatin/NAMPT, resistin, TNF-[alpha], and IL-6 and between the size of the cyst and plasma adipokines levels.
Furthermore, levels of circulating adiponectin and FGF21 which are responsible for maintaining glucose homeostasis were measured to assess the relationship between those secreted proteins and CTRP1.
Total adiponectin and visfatin concentrations were determined by immunoassay (ELISA) (ALPCO Diagnostics, Salem, USA; Ray Biotech Inc.
Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.
sup][5] Adiponectin is a hormone originally identified in adipocytes and is recently shown to modulate a wide range of physiological processes including carbohydrate and lipid metabolism, atherosclerosis, blood pressure regulation, and insulin sensitivity, and even influence immunity and inflammation.
As an endocrine organ, adipose tissue secretes a number of adipokines, including leptin and adiponectin, and constitutes a major source of inflammatory cytokines such as tumor necrosis factor alpha (TNF-[alpha]) and interleukin-6 (IL-6), mediating obesity-related metabolic dysregulation [9-11].