adiponectin


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Related to adiponectin: ghrelin, Resistin

ad·i·po·nec·tin

(ad'i-pō-nek'tin),
Protein hormone produced and secreted by adipocytes into the systemic blood circulation; causes sensitivity of peripheral tissues to insulin.
[adipo- + L. necto, to fasten, + -in]

adiponectin

(ăd′ə-pə-nĕk′tĭn)
n.
A polypeptide hormone that is secreted by fat cells and regulates glucose and lipid metabolism, especially by increasing insulin sensitivity and muscle uptake of glucose and by decreasing glucose production in the liver.

Adiponectin

A circulating protein encoded by ADIPOQ on chromosome 3q27, which is secreted exclusively by mature adipocytes. It is a key adipokine in the control of fat metabolism and insulin sensitivity, and has direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. It stimulates AMPK phosphorylation and activation in the liver and skeletal muscle, enhancing glucose utilisation and fatty acid hydrolysis. It antagonises TNF-alpha by down-regulating its expression in the liver, macrophages and elsewhere, and by counteracting its direct effects. It inhibits endothelial NF-kappa-B signalling by a cAMP-dependent pathway. It may play a role in cell growth, angiogenesis and tissue remodelling by binding and sequestering various growth factors with distinct binding affinities, depending on complex size—low, medium, or high molecular weight.

ad·i·po·nec·tin

(ad'i-pō-nek'tin)
Protective adipokine that reduces lipid accumulation and endothelial adhesion resulting from vascular injury; increases skeletal muscle oxidation of free fatty acids; reduces hepatic glucose output; increases peripheral insulin sensitivity.
[adipo- + L. necto, to fasten, + -in]

adiponectin

A cytokine derived from adipose tissue that has antidiabetic and antiatherosclerotic properties.
References in periodicals archive ?
Our initial findings indicated an indirect relationship between serum adiponectin levels and DFS and Osmic was shown through the stage of the disease.
Serum were analysis for lipid profile (cholesterol, triglyceride, HDLP, LDLP (Human-Germany), adiponectin (Human-Germany), and Hpylori (Eco test-Chain).
Although adiponectin has been shown to regulate fatty acid metabolism, it remains unknown whether adiponectin regulates the expression levels of these adipogenic-related genes.
In those contexts it becomes increasingly clear that measuring adiponectin levels is the most accurate way to assess prediabetes.
Generally, the anti-obesity effects of test materials have been evaluated based on the body and fat weights, and serum or organ lipid profiles with various adipokines like leptin and adiponectin (Sahai et al., 2004; Fujita et al., 2005; Mitchell et al., 2005).
Jara and his co-authors at Ohio State investigated the effects of race and pre-pregnancy BMI on serum adiponectin, leptin, the leptin-to-adiponectin ratio (LAR) throughout pregnancy and postpartum, and their effects on weight gain during pregnancy.
In the present study, we investigated whether rosiglitazone-elicited insulin sensitization is mediated by adipose tissue-derived adiponectin at the adipose tissue-liver axis in the genetically occurred rat model.
To evaluate adiponectin as a marker of DM control, we studied 376 patients with known T2DM duration of 12.4 [+ or -] 8.1 years.
We made a comprehensive literature search of PubMed and Embase databases from their inception to June 2018 using the following search items: "adiponectin" AND "heart failure" AND "rehospitalization" OR "readmission" OR "mortality" OR "death" OR "prognosis" OR "major adverse cardiac events".
The association between circulating adiponectin levels and risk of colorectal cancer has been evaluated in many studies [19-23].
Since chronic inflammation and microvascular changes may play pivotal roles for the pathogenesis and the progression of the disease, we hypothesized associations among adiponectin, TNF-[alpha], ICAM-1, and VCAM-1 in patients with AD.
The adiponectin hormone is secreted exclusively by the adipose tissue and reported to be involved in the above mentioned process since it acts as an antiinflammatory, antioxidant, cytoprotective, and lipid and sugar lowering agent (Yamauchi & Kadowaki, 2008).