Associations of maternal and cord blood adipokines
with offspring adiposity in Project Viva: is there an interaction with child age?
The difference in the vaspin levels between our two groups was statistically significant, and we attributed this difference to the reduction in renal excretion, possibly as in other adipokines
. In our study, a statistically insignificant correlation was found between vaspin and age, and no correlation was observed between serum vaspin level and HOMA-IR and insulin levels in the non-diabetic patients with CKD.
The data demonstrate AgeX's PureStem cell therapy manufacturing platform was successful in generating highly purified cells with precise anatomical identity, and most importantly, capable of potently expressing definitive markers of BAT cells, including active adipokines
such as adiponectin.
Adiponectin, leptin, C-reactive protein, tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) are the main adipokines
produced by adipocytes.
Adipocytes are the main producers of the pro-/anti-inflammatory cytokines called adipokines
. Recent studies suggest that adipokines
(adiponectin, ADIPOQ; leptin, LEP; resistin, RETN) are also secreted by periodontal ligament (PDL) cells, and could be regulated by periodontal pathogens and inflammatory mediators.
Adipose tissue secretes hundreds of adipokines
that regulate important biological processes.
Pregnancy is associated with excess release of many adipokines
and cytokines that contribute to IR.
We understand that the fat tissue is not an inert organ; rather, it is an active endocrine tissue that secretes adipokines
, or cytokines derived from adipocytes.
Generally, the anti-obesity effects of test materials have been evaluated based on the body and fat weights, and serum or organ lipid profiles with various adipokines
like leptin and adiponectin (Sahai et al., 2004; Fujita et al., 2005; Mitchell et al., 2005).
The primary factors of these are adipokines
, PLINs, and gene variations that code them (20).
Several factors termed adipokines
, mainly produced in the adipose tissue have been found to be important regulators in both inflammation and nutrition, which may affect neuroendocrine regulation of pain and fatigue through several pathways (6).
From leptin to other adipokines
in health and disease: Facts and expectations at the beginning of the 21st century.